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POLR3H Mouse anti-Human, Clone: OTI4D8, liquid, TrueMAB™
Mouse Monoclonal Antibody
Supplier: OriGene TA809432
SDSDocumentsProduct Certifications Promotions
DescriptionRPC8 is DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. It is plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. It is acting as nuclear and cytosolic DNA sensor involved in innate immune response. It can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF-Kappa-B through the RIG-I pathway.
|PBS with 1% BSA, 50% glycerol and 0.02% sodium azide|
|Full length human recombit protein of human POLR3H produced in E.coli.|
|Immunohistochemistry (Paraffin), Western Blot|
|-20° C, Avoid Freeze/Thaw Cycles|
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