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  5. Tocris Bioscience™ Poly(I:C)

Tocris Bioscience™ Poly(I:C)
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Catalog No. 428710
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Quantity:
10 mg
50 mg
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

TLR3 agonist

Poly(I:C) is a synthetic double-stranded RNA (dsRNA); endosomal Toll-like receptor 3 (TLR3) agonist. It also binds to the cytoplasmic receptors, retinoic acid-inducible gene I (RIG-I) and melanoma differentiation-associated gene 5 (MDA-5), elicits the secretion of type I interferon (IFN) and pro-inflammatory cytokines. Poly(I:C) is commonly used for immune system activation in vivo. Poly(I:C) also promotes maturation of hPSC-derived cardiomyocytes by modulating early Notch signaling and cardiomyogenic transcriptional programs. Poly(I:C) promotes generation of stable, mature dendritic cells in combination with TLR8 agonist CL 075 . Transfection into NIT-1 β cells induce β-cell apoptosis. Commonly used to stimulate immune system activation in vivo. Also promotes maturation of hPSC-derived cardiomyocytes.

To prevent denaturation, this product should be reconstituted in solutions with physiological salt concentrations.

Chemical Identifiers

CAS 24939-03-5
Molecular Formula C19H27N7O16P2

Specifications

Quantity 10 mg
Purity >98%
Molecular Weight (g/mol) 671.406
Chemical Name or Material Poly(I:C)

Safety and Handling

Recommended Storage Store at -20°C
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