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Invitrogen™ Polyoma Virus Medium T Monoclonal Antibody (PyMT)
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Catalog No. MA146061
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100 μL
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MA146061 100 μL
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Catalog No. MA146061 Supplier Invitrogen™ Supplier No. MA146061
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Description

Rat Monoclonal Antibody

Polyoma Virus Medium T Monoclonal Antibody for ICC/IF, IP, Western Blot

The Polyoma Virus Medium T (MT) antigen is associated with oncogenic processes in the virus's host cells. Polyoma Virus is a small, double-stranded DNA virus that primarily infects mice, leading either to lytic or abortive infections. The MT antigen plays a pivotal role in the virus's ability to induce tumors and transform cells. Structurally, the Polyoma Virus includes multiple T-antigens, with MT being one such protein that resembles growth factor receptors and mimics their function, thereby activating signaling pathways that lead to cell proliferation and transformation. The MT antigen has been extensively studied for its ability to initiate and sustain signaling pathways integral to cancer research, such as activating tyrosine kinases and phosphatidylinositol 3-kinases pathways, which are crucial for cell survival, growth, and division. The coding regions and structure of MT, derived from genetic, mRNA, peptide, and DNA analysis, have established its importance in polyoma's oncogenic activity, offering critical insights into molecular changes underlying tumorigenesis. Understanding the MT antigen's structure and function has significantly contributed to the study of viral mechanisms and cancer development.
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Specifications

Antigen Polyoma Virus Medium T
Applications Immunoprecipitation, Western Blot, Immunocytochemistry
Classification Monoclonal
Clone PyMT
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene Alias MPyVgp2
Host Species Rat
Immunogen Polyoma Virus-transformed Wistar rat fibroblast cell line Py REWA5/T1A1.
Purification Method Protein G
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Target Species Virus
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG2b
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