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Invitrogen™ POMGNT1 Polyclonal Antibody
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Catalog No. PIPA569556
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100 μL
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PIPA569556 100 μL
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Catalog No. PIPA569556 Supplier Invitrogen™ Supplier No. PA569556
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Description

Rabbit Polyclonal Antibody

This target displays homology in the following species: Cow: 86%; Dog: 93%; Guinea Pig: 86%; Horse: 86%; Human: 100%; Mouse: 100%; Pig: 93%; Rabbit: 86%; Rat: 100%.

The product of the POMGNT1 gene, protein O-mannose beta-1,2-N-acetylglucosaminyltransferase, participates in O-mannosyl glycan synthesis. POMGnT1 is an N(in)/C(out) (type II) membrane protein localized in the medial-Golgi that initiates the conversion of high mannose N-glycans to complex N-glycans. Specifically, POMGnT1 is a glycosylation enzyme that participates in the synthesis of O-mannosyl glycan, a laminin-binding ligand of alpha-dystroglycan that is rarely synthesized in mammals. Mutations in the POMGNT1 gene cause muscle-eye-brain disease (MEB), an autosomal recessive disorder characterized by congenital muscular dystrophy, ocular abnormalities and lissencephaly.
TRUSTED_SUSTAINABILITY

Specifications

Antigen POMGNT1
Applications Western Blot
Classification Polyclonal
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 2% sucrose and 0.09% sodium azide
Gene POMGNT1
Gene Accession No. Q91X88
Gene Alias 0610016I07Rik; 4930467B06Rik; GnT I.2; GNTI.2; gnT-I.2; LGMD2O; MDDGA3; MDDGB3; MDDGC3; MEB; MGAT1.2; N-acetylglucosaminyltransferase I.2; O-linked mannose beta1,2-N-acetylglucosaminyltransferase; O-mannosyl N-acetylglucosaminyltransferase; OMGnT1; POMGNT1; protein O-linked mannose beta 1,2-N-acetylglucosaminyltransferase; protein O-linked mannose beta1,2-N-acetylglucosaminyltransferase; protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-); protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1; protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1; LOW QUALITY PROTEIN: protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1; RP11-322N21.3; UDP-GlcNAc:alpha-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I.2; UNQ746/PRO1475
Gene Symbols POMGNT1
Host Species Rabbit
Immunogen synthetic peptide corresponding to a region of mouse POMGNT1 (aa 47-96).
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 68273
Target Species Mouse
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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