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Invitrogen™ POMGNT1 Polyclonal Antibody
Rabbit Polyclonal Antibody
Supplier: Invitrogen™ PA5100281
Description
Antibody detects endogenous levels of total MGAT1.
The product of the POMGNT1 gene, protein O-mannose beta-1,2-N-acetylglucosaminyltransferase, participates in O-mannosyl glycan synthesis. POMGnT1 is an N(in)/C(out) (type II) membrane protein localized in the medial-Golgi that initiates the conversion of high mannose N-glycans to complex N-glycans. Specifically, POMGnT1 is a glycosylation enzyme that participates in the synthesis of O-mannosyl glycan, a laminin-binding ligand of alpha-dystroglycan that is rarely synthesized in mammals. Mutations in the POMGNT1 gene cause muscle-eye-brain disease (MEB), an autosomal recessive disorder characterized by congenital muscular dystrophy, ocular abnormalities and lissencephaly.
Specifications
POMGNT1 | |
Polyclonal | |
Unconjugated | |
POMGNT1 | |
0610016I07Rik; 4930467B06Rik; GnT I.2; GNTI.2; gnT-I.2; LGMD2O; MDDGA3; MDDGB3; MDDGC3; MEB; MGAT1.2; N-acetylglucosaminyltransferase I.2; O-linked mannose beta1,2-N-acetylglucosaminyltransferase; O-mannosyl N-acetylglucosaminyltransferase; OMGnT1; POMGNT1; protein O-linked mannose beta 1,2-N-acetylglucosaminyltransferase; protein O-linked mannose beta1,2-N-acetylglucosaminyltransferase; protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-); protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1; protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1; LOW QUALITY PROTEIN: protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1; RP11-322N21.3; UDP-GlcNAc:alpha-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I.2; UNQ746/PRO1475 | |
Rabbit | |
Affinity Chromatography | |
RUO | |
362567, 55624, 68273 | |
-20°C | |
Liquid |
Western Blot, Immunocytochemistry | |
1 mg/mL | |
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4 | |
Q5XIN7, Q8WZA1, Q91X88 | |
POMGNT1 | |
A synthesized peptide derived from human POMGNT1(Accession Q8WZA1), corresponding to amino acid residues L622-T660. | |
100 μL | |
Primary | |
Human, Mouse, Rat | |
Antibody | |
IgG |
Safety and Handling
WARNING: Cancer - www.P65Warnings.ca.gov
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