Invitrogen™ PON1 Monoclonal Antibody (9D3)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA527877

Catalog No. PIMA527877

Description

Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 μg/mL. Positive Control - WB: mouse liver tissue, mouse liver tissue, rat liver tissue, rat liver tissue.

The paraoxonase (PON) gene-family in humans has three members, PON1, PON2, and PON3, aligned next to each other on the long arm of chromosome 7q21.3-22.1. PON1 of these is synthesized primarily in the liver and a portion is secreted into the plasma, where it is associated with high density lipoproteins (HDL). And It hydrolyzes the active metabolites of several other organophosphorus insecticides (e.g., chlorpyrifos oxon, diazoxon), as well as nerve agents such as sarin, soman and VX (lethal nerve agent). The PON1 polymorphism may be responsible for neurodegeneration and considered to be an independent risk factor for Parkinson's disease.

Specifications

• Antigen: PON1
• Classification: Monoclonal
• Concentration: 500 μg/mL
• Formulation: PBS with 4mg trehalose and 0.05mg sodium azide
• Gene Accession No.: P52430, P55159
• Gene Symbols: PON1
• Immunogen: E. coli-derived mouse PON1 recombinant protein (Position: A30-D274).
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Mouse, Rat
• Product Type: Antibody
• Isotype: IgG2b

• Applications: ELISA, Immunohistochemistry (Paraffin), Western Blot
• Clone: 9D3
• Conjugate: Unconjugated
• Gene: PON1
• Gene Alias: 2810004E20; 6330405I24Rik; A esterase 1; A-esterase 1; A-esterase 2; AI481612; AI786302; Aromatic esterase 1; aromatic esterase 2; arylesterase 1; arylesterase 2; arylesterase 3; arylesterase B-type; EC 3.1.1.2; EC 3.1.1.81; EC 3.1.8.1; ESA; ESAesterase A; esterase A; K-45; MVCD5; paraoxanase-3; paraoxonase 1; paraoxonase 2; paraoxonase 3; paraoxonase B-type; paraoxonase nirs; PON; PON 1; PON 2; Pon1; PON2; PON3; serum aryldiakylphosphatase; serum aryldialkylphosphatase 1; Serum aryldialkylphosphatase 2; serum paraoxonase/arylesterase 1; Serum paraoxonase/arylesterase 2; serum paraoxonase/lactonase 3
• Host Species: Mouse
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 18979, 84024
• Content And Storage: -20°C
• Form: Lyophilized