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Invitrogen™ PON1 Polyclonal Antibody
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Catalog No. PIPA596644
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100 μL
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PIPA596644 100 μL
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Catalog No. PIPA596644 Supplier Invitrogen™ Supplier No. PA596644
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: HQSSYQTRLN ALREVQPVEL PNCNLVKGIE TGSEDLEILP NGLAFISSGL KYPGIKSFNP NSPGKILLMD LNEEDPTVLE LGITGSKFDV SSFNPHGIST FTDEDNAMYL LVVNHPDAKS TVELFKFQEE E; Positive Samples: 293T, Jurkat, Mouse thymus, Mouse heart, Rat liver; Cellular Location: extracellular space.

The paraoxonase (PON) gene-family in humans has three members, PON1, PON2, and PON3, aligned next to each other on the long arm of chromosome 7q21.3-22.1. PON1 of these is synthesized primarily in the liver and a portion is secreted into the plasma, where it is associated with high density lipoproteins (HDL). And It hydrolyzes the active metabolites of several other organophosphorus insecticides (e.g., chlorpyrifos oxon, diazoxon), as well as nerve agents such as sarin, soman and VX (lethal nerve agent). The PON1 polymorphism may be responsible for neurodegeneration and considered to be an independent risk factor for Parkinson's disease.
TRUSTED_SUSTAINABILITY

Specifications

Antigen PON1
Applications ELISA, Western Blot
Classification Polyclonal
Concentration 0.98 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene PON1
Gene Accession No. P27169, P52430, P55159
Gene Alias 2810004E20; 6330405I24Rik; A esterase 1; A-esterase 1; A-esterase 2; AI481612; AI786302; Aromatic esterase 1; aromatic esterase 2; arylesterase 1; arylesterase 2; arylesterase 3; arylesterase B-type; EC 3.1.1.2; EC 3.1.1.81; EC 3.1.8.1; ESA; ESAesterase A; esterase A; K-45; MVCD5; paraoxanase-3; paraoxonase 1; paraoxonase 2; paraoxonase 3; paraoxonase B-type; paraoxonase nirs; PON; PON 1; PON 2; Pon1; PON2; PON3; serum aryldiakylphosphatase; serum aryldialkylphosphatase 1; Serum aryldialkylphosphatase 2; serum paraoxonase/arylesterase 1; Serum paraoxonase/arylesterase 2; serum paraoxonase/lactonase 3
Gene Symbols PON1
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 20-150 of human PON1 (NP_0004373).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 18979, 5444, 84024
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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