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Invitrogen™ PON1 Polyclonal Antibody
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Catalog No. PIPA579844
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100 μg
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PIPA579844 100 μg
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Catalog No. PIPA579844 Supplier Invitrogen™ Supplier No. PA579844
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Description

Rabbit Polyclonal Antibody

Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 μg/mL. Positive Control - WB: Rat Liver Tissue, Rat Lung Tissue, Human Placenta Tissue, Rat Testis Tissue, HELA whole cell, HEPA whole cell, A549 whole cell, JURKAT whole cell, SKOV whole cell.

The paraoxonase (PON) gene-family in humans has three members, PON1, PON2, and PON3, aligned next to each other on the long arm of chromosome 7q21.3-22.1. PON1 of these is synthesized primarily in the liver and a portion is secreted into the plasma, where it is associated with high density lipoproteins (HDL). And It hydrolyzes the active metabolites of several other organophosphorus insecticides (e.g., chlorpyrifos oxon, diazoxon), as well as nerve agents such as sarin, soman and VX (lethal nerve agent). The PON1 polymorphism may be responsible for neurodegeneration and considered to be an independent risk factor for Parkinson's disease.
TRUSTED_SUSTAINABILITY

Specifications

Antigen PON1
Applications Western Blot
Classification Polyclonal
Concentration 500 μg/mL
Conjugate Unconjugated
Formulation PBS with 5mg BSA and 0.05mg sodium azide, 0.05mg thimerosal
Gene PON1
Gene Accession No. P27169, P52430, P55159
Gene Alias 2810004E20; 6330405I24Rik; A esterase 1; A-esterase 1; A-esterase 2; AI481612; AI786302; Aromatic esterase 1; aromatic esterase 2; arylesterase 1; arylesterase 2; arylesterase 3; arylesterase B-type; EC 3.1.1.2; EC 3.1.1.81; EC 3.1.8.1; ESA; ESAesterase A; esterase A; K-45; MVCD5; paraoxanase-3; paraoxonase 1; paraoxonase 2; paraoxonase 3; paraoxonase B-type; paraoxonase nirs; PON; PON 1; PON 2; Pon1; PON2; PON3; serum aryldiakylphosphatase; serum aryldialkylphosphatase 1; Serum aryldialkylphosphatase 2; serum paraoxonase/arylesterase 1; Serum paraoxonase/arylesterase 2; serum paraoxonase/lactonase 3
Gene Symbols PON1
Host Species Rabbit
Immunogen A synthetic peptide corresponding to a sequence in the middle region of human PON1 (186-201aa FLDPYLQSWEMYLGLA).
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 18979, 5444, 84024
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Lyophilized
Isotype IgG
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