Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
  1. Home
  2. Products
  3. Antibodies
  4. Primary Antibodies
  5. All Primary Antibodies
  6. PIPA582512

Invitrogen™ PON3 Polyclonal Antibody
GREENER_CHOICE

Catalog No. PIPA582512
Change view
Click to view available options
Quantity:
100 μL
1 product options available for selection
Product selection table with 1 available options. Use arrow keys to navigate and Enter or Space to select.
Catalog No. Quantity
PIPA582512 100 μL
Use arrow keys to navigate between rows. Press Enter or Space to select a product option. 1 options available.
1 options
Catalog No. PIPA582512 Supplier Invitrogen™ Supplier No. PA582512
Add to Cart
Add to Cart

Description

Rabbit Polyclonal Antibody

Immunogen sequence: REVEPVEPEN CHLIEELESG SEDIDILPSG LAFISSGLKY PGMPNFAPDE PGKIFLMDLN EQNPRAQALE ISGGFDKELF NPHGISIFID KDNTVYLYVV NHP Highest antigen sequence indentity to the following orthologs: Rat - 81%, Mouse - 83%.

Paraoxonase-1 (PON1) is a calcium-dependent ester hydrolase that is tightly associated with apoA-I in HDL. PON1 prevents the oxidation of LDL, thereby the formation of atherogenic oxidised-LDL. Polymorphisms of the human PON1 gene are correlated with coronary artery disease, indicating a genetic association between PON1 and coronary artery disease. PON1 activity is lower in subjects prone to development of atherosclerosis such as in type 1 and type 2 diabetes, familial hypercholesterolemia, and renal disease, indicating the involvement of PON1 in atherosclerosis development. PON2 is a ubiquitously expressed intracellular protein that can protect cells against oxidative damage. PON3 is similar to PON1 in activity but differs from it in substrate specificity. PON1 and PON3 are implicated in lowering the risk of developing coronary artery disease and atherosclerosis. Human PON3 protein shares the 3 conserved cysteine residues identified in PON1, suggesting their importance of in vivo activities. PON1-based catalytic scavengers can be a way to safe and effective organophosphate intoxication.
TRUSTED_SUSTAINABILITY

Specifications

Antigen PON3
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 0.1 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene PON3
Gene Accession No. Q15166
Gene Alias 2810004E20; AI786302; arylesterase 3; lactonase/esterase; paraoxanase-3; paraoxonase 3; PON3; Serum paraoxonase/lactonase 3
Gene Symbols PON3
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human PON3. Recombinant protein control fragment (Product #RP-90062).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 5446
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
Show More Show Less

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
Product Title
Select an issue

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.