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Invitrogen™ PON3 Polyclonal Antibody
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Catalog No. PIPA5116681
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PIPA5116681 100 μL
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Catalog No. PIPA5116681 Supplier Invitrogen™ Supplier No. PA5116681
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Description

Rabbit Polyclonal Antibody

Positive Samples: Jurkat, HepG2 Immunogen sequence: HDNWDLTQLK VIQLGTLVDN LTVDPATGDI LAGCHPNPMK LLNYNPEDPP GSEVLRIQNV LSEKPRVSTV YANNGSVLQG TSVASVYHGK ILIGTVFHKT L.

Paraoxonase-1 (PON1) is a calcium-dependent ester hydrolase that is tightly associated with apoA-I in HDL. PON1 prevents the oxidation of LDL, thereby the formation of atherogenic oxidised-LDL. Polymorphisms of the human PON1 gene are correlated with coronary artery disease, indicating a genetic association between PON1 and coronary artery disease. PON1 activity is lower in subjects prone to development of atherosclerosis such as in type 1 and type 2 diabetes, familial hypercholesterolemia, and renal disease, indicating the involvement of PON1 in atherosclerosis development. PON2 is a ubiquitously expressed intracellular protein that can protect cells against oxidative damage. PON3 is similar to PON1 in activity but differs from it in substrate specificity. PON1 and PON3 are implicated in lowering the risk of developing coronary artery disease and atherosclerosis. Human PON3 protein shares the 3 conserved cysteine residues identified in PON1, suggesting their importance of in vivo activities. PON1-based catalytic scavengers can be a way to safe and effective organophosphate intoxication.
TRUSTED_SUSTAINABILITY

Specifications

Antigen PON3
Applications ELISA, Western Blot
Classification Polyclonal
Concentration 0.07 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
Gene PON3
Gene Accession No. Q15166
Gene Alias 2810004E20; AI786302; arylesterase 3; lactonase/esterase; paraoxanase-3; paraoxonase 3; PON3; Serum paraoxonase/lactonase 3
Gene Symbols PON3
Host Species Rabbit
Immunogen A synthetic peptide corresponding to a sequence within amino acids 250-350 of human PON3 (NP_0009311).
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 5446
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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