POT1 Rabbit anti-Human, Mouse, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Supplier:  Proteintech Group Inc 105811AP150UL

Catalog No. 50-172-6422

Description

POT1 is a component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini. It is a component of the double-stranded telomeric DNA-binding TRF1 complex which is involved in the regulation of telomere length by cis-inhibition of telomerase. Pot1 also acts as a single-stranded telomeric DNA-binding protein and thus may act as a downstream effector of the TRF1 complex and may transduce information about telomere maintece and/or length to the telomere terminus. It binds to two or more telomeric single-stranded 5′-TTAGGG-3′ repeats (G-strand) and with high specificity to a minimal telomeric single-stranded 5′-TAGGGTTAG-3′ sequence. Its activity is TERT dependent but it does not increase TERT activity.

Specifications

• Antigen: POT1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: POT1
• Gene Alias: hPot1, POT1
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 101185, 25913
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.3 mg/mL
• Formulation: PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
• Gene Accession No.: Q91WC1, Q9NUX5
• Gene Symbols: Pot1
• Immunogen: POT1 Fusion Protein Ag0875
• Quantity: 150 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG