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Invitrogen™ PP2A B-alpha Monoclonal Antibody (2G9)
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Catalog No. PIMA518064
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100 μL
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PIMA518064 100 μL
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Catalog No. PIMA518064 Supplier Invitrogen™ Supplier No. MA518064
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Description

Mouse Monoclonal Antibody

This antibody reacts very strongly with rat alpha and delta isoforms, and weakly with the human beta and rabbit gamma isoforms. This antibody is predicted to react with porcine, rabbit, chicken and xenopus samples based on sequence homology.

PPP2R2A (Protein Phosphatase 2 Regulatory Subunit Balpha) is a Protein Coding gene. Diseases associated with PPP2R2A include Lung Cancer and Hepatocellular Carcinoma. Among its related pathways are Cell Cycle, Mitotic and p70S6K Signaling. Gene Ontology (GO) annotations related to this gene include protein serine/threonine phosphatase activity and protein phosphatase regulator activity. An important paralog of this gene is PPP2R2D. The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. Essential for serine/threonine-protein phosphatase 2A-mediated dephosphorylation of WEE1, preventing its ubiquitin-mediated proteolysis, increasing WEE1 protein levels, and promoting the G2/M checkpoint. The product of this gene belongs to the phosphatase 2 regulatory subunit B family. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes an alpha isoform of the regulatory subunit B55 subfamily. Alternatively spliced transcript variants have been described.
TRUSTED_SUSTAINABILITY

Specifications

Antigen PP2A B-alpha
Applications Immunoprecipitation, Western Blot
Classification Monoclonal
Clone 2G9
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.1% sodium azide
Gene Ppp2r2a
Gene Accession No. P36876, P63151, Q6P1F6
Gene Alias PP2Ac; PP2CA; PP2Calpha; RP-C; PP2A-alpha; protein phosphatase 2; protein phosphatase 2A catalytic subunit; replication protein C; serine/threonine protein phosphatase 2A; catalytic subunit
Gene Symbols Ppp2r2a
Host Species Mouse
Immunogen Peptide from rat PP2A isoform alpha (Immunogen sequence: 398-CASGKRKKDEISVD-411).
Purification Method Protein G
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 117104, 5520, 71978
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG1
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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