MilliporeSigma™ PP2A B subunit isoform B56-gamma, Rabbit, Unlabeled, Polyclonal,

Rabbit Polyclonal Antibody

Supplier:  MilliporeSigma™ ABS1606

Catalog No. ABS1606MI

Description

Serine/threonine-protein phosphatase 2A 56kDa regulatory subunit gamma isoform (UniProt Q13362; also known as PP2A B subunit isoform B&prime-gamma, PP2A B subunit isoform B56-gamma, PP2A B subunit isoform PR61-gamma, PP2A B subunit isoform R5-gamma, Renal carcinoma antigen NY-REN-29) is encoded by the PPP2R5C (also known as KIAA0044) gene (Gene ID 5527) in human. Protein phosphatase 2 (PP2 or PP2A) is a ubiquitously expressed heterotrimeric serine/threonine protein phosphatase with broad substrate specificity, such as Raf, MEK, and AKT. PP2A is composed of a structural A and a catalytic C subunit as the dimeric core enzyme, and a regulatory B subunit. There exist two different A subunits (PPP2R1A and PPP2R1B), two different C subunits (PPP2CA and PPP2CB), and 12 different B subunits (PPP2R2B-D, PPP2R3A-C, PPP2R4, PPP2R5A-E). The enzymatic activity of a catalytic subunit is altered upon binding an A subunit even in the absence of a B subunit. The B subunits are believed to play key roles in controlling the localization and specific activity of the A/C holoenzymes.

Specifications

• Antigen: PP2A B subunit isoform B56-gamma
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: PPP2R5C, KIAA0044
• Host Species: Rabbit
• Purification Method: Unpurified
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Test Specificity: This antiserum is also known as M880 (Okamoto, K., et al. (1996). Mol. Cell. Biol. 16(11):6593-6602). Immunogen sequence is 100% present in human PPP2R5C spliced isoform 5 and Gamma-3, with the first amino acid missing in isoform 4 and Gamma-2. PPP2R5C spliced isoform Gamma-3 (UniProt Q13362-1) and Gamma-2 (UniProt Q13362-3) were originally referred to as B'α1 and B'α2, respectively (Tehrani, M.A., et al. (1996). J. Biol. Chem. 271(9):5164-5170). The Immunogen sequence is not present in PPP2R5C isoform Gamma-1 or any of the spliced isoforms of the other 11 types of human PP2A B subunits (PPP2R2B, PPP2R2C, PPP2R2D, PPP2R3A, PPP2R3B, PPP2R3C, PPP2R4, PPP2R5A, PPP2R5B, PPP2R5D, PPP2R5E).
• Content And Storage: Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.

• Applications: Immunoprecipitation, Western Blot
• Concentration: Please refer to lot specific datasheet.
• Formulation: Rabbit polyclonal antibody serum with 0.05% Sodium Azide.
• Gene Accession No.: Q13362
• Immunogen: KLH-conjugated linear peptide corresponding to a C-terminal sequence of human PP2A B subunit isoform B56-gamma.
• Quantity: 100 μL
• Research Discipline: Signaling
• Gene ID (Entrez): NP_002710
• Target Species: Human
• Form: Serum

For Research Use Only. Not for use in diagnostic procedures.