PP2CA Rabbit anti-Human, Polyclonal, Bioss

Catalog No.	Quantity
50-198-5941	100 μL

Catalog No. 50-198-5941 Supplier Bioss Supplier No. BS4162R

Description

Rabbit Polyclonal Antibody

The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase dephosphorylates, and negatively regulates the activities of, MAP kinases and MAP kinase kinases. It has been shown to inhibit the activation of p38 and JNK kinase cascades induced by environmental stresses. This phosphatase can also dephosphorylate cyclin-dependent kinases, and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to activate the expression of the tumor suppressor gene TP53/p53, which leads to G2/M cell cycle arrest and apoptosis. Three alternatively spliced transcript variants encoding distinct isoforms have been described.

Specifications

• Antigen: PP2CA
• Applications: Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
• Classification: Polyclonal
• Concentration: 1 μg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
• Gene: PPP2CA
• Gene Accession No.: P35813, P67775
• Gene Alias: 2310003C21Rik; 2900017D14Rik; AI427932; AU017636; IA; MMPa-2; Mpp alpha; MPPa-1; PP2A; Pp2a1; PP2A-alpha; PP2Ac; Pp2c1; PP2CA; PP2Calpha; PP2C-alpha; PPM1A; Ppp2ca; PPPM1A; Protein phosphatase 1A; protein phosphatase 1A (formerly 2C), magnesium-dependent, alpha isoform; protein phosphatase 1A, magnesium dependent, alpha isoform; protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform; protein phosphatase 2 catalytic subunit alpha; protein phosphatase 2, catalytic subunit, alpha isoform; protein phosphatase 2, catalytic subunit, alpha isozyme; protein phosphatase 2a, catalytic subunit, alpha isoform; Protein phosphatase 2C isoform alpha; Protein phosphatase IA; Protein phosphatase type 1A (formely 2C) Mg-dependent alpha isoform; Protein phosphatase type 1A (formely 2C), Mg-dependent, alpha isoform; protein phosphatase, Mg2+/Mn2+ dependent 1A; protein phosphatase, Mg2+/Mn2+ dependent, 1A; protein phosphatase-2A-alpha; R75353; Replication protein C; RP-C; serine/threonine protein phosphatase 2A, catalytic subunit, alpha isoform; Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
• Gene Symbols: Ppm1a, PPP2CA
• Host Species: Rabbit
• Immunogen: KLH conjugated synthetic peptide derived from human PP2CA.
• Purification Method: Protein A
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 5494, 5515
• Target Species: Human
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG