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  6. PPARA Monoclonal Antibody (OTI2D10), TrueMAB™, OriGene 

PPARA Monoclonal Antibody (OTI2D10), TrueMAB™, OriGene
SDP

Catalog No. 501674396
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30 μL
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Catalog No. Quantity
50-167-4396 100 μL
50-254-0858 30 μL
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Catalog No. 50-167-4396 Supplier OriGene Supplier No. TA503529
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Description

Mouse Monoclonal Antibody

Peroxisome proliferator-activated receptor alpha (PPARA) is a member of the nuclear hormone receptor subfamily. Upon activation, PPARA forms heterodimers with retinoid X receptors (RXRs), and functions to regulatetranscrption of specific gene sequences. In particular, PPARA controls genes involved in the peroxisomal and mitochondrial beta oxidation pathways, fatty acid uptake, and triglyceride catabolism in the liver and skeletal muscle. PPARA also has anti-inflammatory and anti-proliferative effects and prevents the proatherogenic effects of cholesterol accumulation in macrophages by stimulating cholesterol efflux. PPARA is the main target of fibrate drugs; hypolipidemic agents used in the treatment of dyslipidemia and the prevention of cardiovascular disease. They could also be used for the treatment of type II diabetes.

Specifications

Antigen PPARA
Applications Flow Cytometry, Immunocytochemistry, Immunofluorescence, Western Blot
Classification Monoclonal
Clone OTI2D10
Concentration 0.48 mg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
Gene PPARA
Gene Accession No. Q07869
Gene Alias NR1C1, PPAR, PPARalpha, hPPAR
Gene Symbols PPARA
Host Species Mouse
Immunogen Human recombit protein fragment corresponding to amino acids 145-420 of human PPARA produced in E.coli.
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 5465
Target Species Human
Content And Storage -20° C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG1
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