PPARA Mouse anti-Human, Mouse, Clone: OTI1E8, lyophilized, TrueMAB™

Mouse Monoclonal Antibody

Supplier:  OriGene CF503540

Catalog No. 50-166-2203

Description

Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO

Peroxisome proliferator-activated receptor alpha (PPARA) is a member of the nuclear hormone receptor subfamily. Upon activation, PPARA forms heterodimers with retinoid X receptors (RXRs), and functions to regulatetranscrption of specific gene sequences. In particular, PPARA controls genes involved in the peroxisomal and mitochondrial beta oxidation pathways, fatty acid uptake, and triglyceride catabolism in the liver and skeletal muscle. PPARA also has anti-inflammatory and anti-proliferative effects and prevents the proatherogenic effects of cholesterol accumulation in macrophages by stimulating cholesterol efflux. PPARA is the main target of fibrate drugs; hypolipidemic agents used in the treatment of dyslipidemia and the prevention of cardiovascular disease. They could also be used for the treatment of type II diabetes.

Specifications

• Antigen: PPARA
• Classification: Monoclonal
• Conjugate: Unconjugated
• Gene: PPARA
• Gene Alias: NR1C1, PPAR, PPARalpha, hPPAR
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 19013, 5465
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized

• Applications: Immunocytochemistry, Immunofluorescence, Western Blot
• Clone: OTI1E8
• Formulation: PBS with 8% trehalose and no preservative; pH 7.3
• Gene Accession No.: P23204, Q07869
• Gene Symbols: PPARA
• Immunogen: Human recombit protein fragment corresponding to amino acids 145-420 of human PPARA produced in E.coli.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG1