PPARD Mouse anti-Human, Clone: OTI4D10, lyophilized, TrueMAB™

Mouse Monoclonal Antibody

Supplier:  OriGene CF811238

Catalog No. 50-167-0544

Description

Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO

This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) family. PPARs are nuclear hormone receptors that bind peroxisome proliferators and control the size and number of peroxisomes produced by cells. PPARs mediate a variety of biological processes, and may be involved in the development of several chronic diseases, including diabetes, obesity, atherosclerosis, and cancer. This protein is a potent inhibitor of ligand-induced transcription activity of PPAR alpha and PPAR gamma. It may function as an integrator of transcription repression and nuclear receptor signaling. The expression of this gene is found to be elevated in colorectal cancer cells. The elevated expression can be repressed by adenomatosis polyposis coli (APC), a tumor suppressor protein related to APC/beta-catenin signaling pathway. Knockout studies in mice suggested the role of this protein in myelination of the corpus callosum, lipid metabolism, and epidermal cell proliferation.

Specifications

• Antigen: PPARD
• Classification: Monoclonal
• Conjugate: Unconjugated
• Gene: PPARD
• Gene Alias: FAAR, NR1C2, NUC1, NUCI, NUCII, PPARB
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 5467
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Clone: OTI4D10
• Formulation: PBS with 8% trehalose and no preservative; pH 7.3
• Gene Accession No.: Q03181
• Gene Symbols: PPARD
• Immunogen: Human recombit protein fragment corresponding to amino acids 1-244 of human PPARD produced in E.coli.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1