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Invitrogen™ PPBP Polyclonal Antibody
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Catalog No. PA551254
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100 μL
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PA551254 100 μL
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Catalog No. PA551254 Supplier Invitrogen™ Supplier No. PA551254
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Description

Rabbit Polyclonal Antibody

The antibody detects endogenous levels of total PPBP protein.

Members of the a-chemokine subfamily of inducible, secreted, pro-inflammatory cytokines contain a similar motif, in which the first two cysteine residues are separated by a single residue (Cys-X-Cys), and are also chemotactic for neutrophils. The platelet basic protein (PBP), a member of the a-chemokine family, resides in the a-granules of platelets and is released upon their activation. Proteolytic cleavage of the amino terminus of PBP leads to the generation of several peptides, which include mature PBP, connective tissue-activating peptide III (CTAP III, also designated low affinity platelet factor IV (LA-PF4)), b-thromboglobulin (b-TG), and neutrophil-activating peptide 2 (NAP-2). PBP and its N-truncated derivatives mediate inflammation and wound healing. Specifically, NAP-2 activates chemotaxis and degranulation in neutrophils during inflammation. The gene encoding human PBP maps to chromosome 4q12-q13.
TRUSTED_SUSTAINABILITY

Specifications

Antigen PPBP
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 2.1 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.05% sodium azide; pH 7.4
Gene PPBP
Gene Accession No. P02775
Gene Alias 2400003M24Rik; AI854500; Beta-TG; Beta-thromboglobulin; b-TG1; chemokine (C-X-C motif) ligand 7; connective tissue-activating peptide III; Connective tissue-activating peptide III(1-81); CTAP3; CTAPIII; CTAP-III; CTAP-III(1-81); CXC chemokine ligand 7; C-X-C motif chemokine 7; CXCL7; LA-PF4; LDGF; Leukocyte-derived growth factor; low-affinity platelet factor IV; Macrophage-derived growth factor; MDGF; NAP-2; NAP-2(1-63); NAP-2(1-66); NAP-2(73); NAP-2(74); NAP-2-L1; neutrophil activating peptide-2; neutrophil-activating peptide 2; Neutrophil-activating peptide 2(1-63); Neutrophil-activating peptide 2(1-66); Neutrophil-activating peptide 2(73); Neutrophil-activating peptide 2(74); neutrophil-activating peptide-2; PBP; Platelet basic protein; PPBP; pro-platelet basic protein; pro-platelet basic protein (chemokine (C-X-C motif) ligand 7); SCYB7; small inducible cytokine B7; small inducible cytokine subfamily B, member 7; small-inducible cytokine B7; TC1; TC-1; TC2; TC-2; TGB; TGB1; THBGB; THBGB1; thrombocidin 1; thrombocidin 2; thromboglobulin, beta-1
Gene Symbols PPBP
Host Species Rabbit
Immunogen Synthetic peptide of human PPBP.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 5473
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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