Invitrogen™ PPIP5K2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA529340

Catalog No. PIPA529340

Description

Recommended positive controls: Raji, K562. Predicted reactivity: Mouse (99%), Rat (97%), Xenopus laevis (94%), Bovine (99%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

PPIP5K2, also known as inositol hexakisphosphate and diphosphoinositol pentakisphosphate kinase 2, is a gene located on chromosome 5 in humans. This gene encodes a kinase involved in the phosphorylation of inositol pyrophosphates, which are essential for cellular signaling and regulation processes. Specifically, PPIP5K2 phosphorylates InsP6 and 1-InsP7 at the 5 position, playing a significant role in both cellular proliferation and metastasis. Recent studies have shown that PPIP5K2 can facilitate the growth and spread of non-small lung cancer (NSCLC) and colorectal carcinoma. It promotes cellular proliferation and migration independent of its kinase activity, in part by modifying its interaction with proteins like 14-3-3, affecting its subcellular distribution. Structural analysis of PPIP5K2 reveals that it possesses unique kinetic properties distinct from other inositol kinase isoforms. Genetic variants, such as the Arg837His missense variant, can alter its phosphatase activity, potentially impacting its functionality in signaling pathways. PPIP5K2 is intricately involved in epithelial-mesenchymal transition (EMT) mechanisms, further influencing cancer cell metastasis. Understanding the biochemical pathways and genetic variations associated with PPIP5K2 is crucial in comprehending its role in disease pathogenesis and therapeutic targeting.

Specifications

• Antigen: PPIP5K2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: PPIP5K2
• Gene Alias: AW555814; CFAP160; D330021B20; diphosphoinositol pentakisphosphate kinase 2; Hisppd1; histidine acid phosphatase domain containing 1; histidine acid phosphatase domain-containing protein 1; hsVIP2; inositol heptaphosphate kinase 2; inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2; InsP6 and PP-IP5 kinase 2; IP7K2; KIAA0433; LOW QUALITY PROTEIN: inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2; mKIAA0433; mmVIP2; PPIP5K2; VIP1 homolog 2; Vip2
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 23262
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 20% glycerol and 0.01% thimerosal; pH 7
• Gene Accession No.: O43314
• Gene Symbols: PPIP5K2
• Immunogen: Recombinant protein encompassing a sequence within the N-terminus region of human HISPPD1. The exact sequence is proprietary.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG