Invitrogen™ Periplakin Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA563784

Catalog No. PIPA563784

Description

Immunogen sequence: AKEERINKLH SEGDQLLAAE HPGRNSIEAH MEAVHADWKE YLNLLICEES HLKYMEDYHQ FHEDVKDAQE LLRKVDSDLN QKYGPDFKDR YQIELLL Highest antigen sequence identity to the following orthologs: Mouse - 94%, Rat - 94%.

The protein encoded by this gene is a component of desmosomes and of the epidermal cornified envelope in keratinocytes. The N-terminal domain of this protein interacts with the plasma membrane and its C-terminus interacts with intermediate filaments. Through its rod domain, this protein forms complexes with envoplakin. This protein may serve as a link between the cornified envelope and desmosomes as well as intermediate filaments. AKT1/PKB, a protein kinase mediating a variety of cell growth and survival signaling processes, is reported to interact with this protein, suggesting a possible role for this protein as a localization signal in AKT1-mediated signaling.

Specifications

• Antigen: Periplakin
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Ppl
• Gene Alias: 190 kDa paraneoplastic pemphigus antigen; 195 kDa cornified envelope precursor protein; 195kDa protein; AW553870; KIAA0568; MGC134872; Periplakin; Ppl
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 5493
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.1 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: O60437
• Gene Symbols: Ppl
• Immunogen: Recombinant protein corresponding to Human PPL. Recombinant protein control fragment (Product #RP-103939).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG