Invitrogen™ Periplakin Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA530931

Catalog No. PIPA530931

Description

Recommended positive controls: U87-MG. Predicted reactivity: Mouse (91%), Rat (91%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

The protein encoded by this gene is a component of desmosomes and of the epidermal cornified envelope in keratinocytes. The N-terminal domain of this protein interacts with the plasma membrane and its C-terminus interacts with intermediate filaments. Through its rod domain, this protein forms complexes with envoplakin. This protein may serve as a link between the cornified envelope and desmosomes as well as intermediate filaments. AKT1/PKB, a protein kinase mediating a variety of cell growth and survival signaling processes, is reported to interact with this protein, suggesting a possible role for this protein as a localization signal in AKT1-mediated signaling.

Specifications

• Antigen: Periplakin
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Ppl
• Gene Alias: 190 kDa paraneoplastic pemphigus antigen; 195 kDa cornified envelope precursor protein; 195kDa protein; AW553870; KIAA0568; MGC134872; Periplakin; Ppl
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 19041, 5493
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 1% BSA, 20% glycerol and 0.01% thimerosal; pH 7
• Gene Accession No.: O60437, Q9R269
• Gene Symbols: Ppl
• Immunogen: Recombinant protein encompassing a sequence within the N-terminus region of human Periplakin. The exact sequence is proprietary.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov