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Tocris Bioscience™ PPM-3

Catalog No. 81165
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Catalog No.
81-165 5 mg
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Catalog No. 81-165 Supplier Tocris Bioscience™ Supplier No. 8116/5
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Description

Potent and selective ERK5 Degrader (PROTAC™)

PPM-3 is a potent and selective ERK5 Degrader (PROTAC™) (IC50 = 62.4 nM). PPM-3 degrades ERK5 in HCT116, h1975, HepG2, MDA-MB-231, PC-3, and A375 tumor cell lines (DC50 values are 5.6, 11.5, 13.7, 22.7, 23.5 and 41.4 nM respectively). PPM-3 has no effect on tumor cell growth directly but influences tumor development by affecting the differentiation of macrophages.

Specifications

Chemical Name or Material (2S,4R)-1-((S)-2-(7-(4-(4-((5,11-Dimethyl-6-oxo-6,11-dihydro-5H-benzo[e]pyrimido[5,4-b][1,4]diazepin-2-yl)amino)-3-methoxyphenyl)piperazin-1-yl)heptanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carbo
CAS 3032388-42-1
Quantity 5 mg
Target Active Degraders
Molecular Formula C54H69N11O6S
Purity 0.98
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