Invitrogen™ PPP1R1A Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA537201

Catalog No. PIPA537201

Description

This antibody detects endogenous protein at a molecular weight of 27 kDa. Purity is >95% by SDS-PAGE.

Protein phosphatase inhibitor-1 (also designated inhibitor of protein phospha-tase 1, IPP-1 and I-1) plays a role in regulating the phosphorylation of other proteins, and is itself phosphorylated by a cyclic AMP-dependent protein kinase at Threonine 35. In addition, the proline-directed kinases Cdk1, Cdk5, and mitogen-activated protein kinase (MAPK) mediate in vitro phosphorylation of IPP-1 at the phylogenetically conserved position Serine 67. In striatal tissues, glutamate-dependent regulation of N-methyl-d-aspartic acid-type channels influences IPP-1 phosphorylation at Ser 67. The localization and expression of IPP-1 suggests that it may play discrete roles in certain regions and developing stages of the brain, independent of the regulation of protein phosphatase type 1 (PP-1). PP-1 binds to both phosphorylated and dephosphorylated IPP-1. Conversion of PP-1 to a Mn++-dependent state appears to play a role in its regulation by IPP-1. IPP-1 attenuates the activity of glycogen phosphorylase and is thought to be important in the hormonal control of glycogen metabolism.

Specifications

• Antigen: PPP1R1A
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Ppp1r1a
• Gene Alias: 0610038N18Rik; I1; I-1; inhibitor-1; Ipp1; IPP-1; PP1 inhibitor 1; Ppp1r1a; protein phosphatase 1 regulatory inhibitor subunit 1A; protein phosphatase 1 regulatory subunit 1A; protein phosphatase 1, regulatory (inhibitor) subunit 1A; protein phosphatase inhibitor 1; protein phosphatase inhibitor-1
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 5502, 58200, 58977
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide
• Gene Accession No.: P19103, Q13522, Q9ERT9
• Gene Symbols: Ppp1r1a
• Immunogen: A synthetic peptide corresponding to residues in human PPP1R1A.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG