Invitrogen™ PPP1R1A Polyclonal Antibody

Catalog No.	Quantity
PIPA559618	100 μL

Catalog No. PIPA559618 Supplier Invitrogen™ Supplier No. PA559618

Description

Rabbit Polyclonal Antibody

Immunogen sequence: AESTETQESR PPGIPDTEVE SRLGTSGTAK KTAECIPKTH ERGSKEPSTK EPSTHIPPLD SKGANSV Highest antigen sequence identity to the following orthologs: Mouse - 57%, Rat - 60%.

Protein phosphatase inhibitor-1 (also designated inhibitor of protein phospha-tase 1, IPP-1 and I-1) plays a role in regulating the phosphorylation of other proteins, and is itself phosphorylated by a cyclic AMP-dependent protein kinase at Threonine 35. In addition, the proline-directed kinases Cdk1, Cdk5, and mitogen-activated protein kinase (MAPK) mediate in vitro phosphorylation of IPP-1 at the phylogenetically conserved position Serine 67. In striatal tissues, glutamate-dependent regulation of N-methyl-d-aspartic acid-type channels influences IPP-1 phosphorylation at Ser 67. The localization and expression of IPP-1 suggests that it may play discrete roles in certain regions and developing stages of the brain, independent of the regulation of protein phosphatase type 1 (PP-1). PP-1 binds to both phosphorylated and dephosphorylated IPP-1. Conversion of PP-1 to a Mn++-dependent state appears to play a role in its regulation by IPP-1. IPP-1 attenuates the activity of glycogen phosphorylase and is thought to be important in the hormonal control of glycogen metabolism.

Specifications

• Antigen: PPP1R1A
• Applications: Immunohistochemistry (Paraffin), Western Blot
• Classification: Polyclonal
• Concentration: 0.3 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene: Ppp1r1a
• Gene Accession No.: Q13522
• Gene Alias: 0610038N18Rik; I1; I-1; inhibitor-1; Ipp1; IPP-1; PP1 inhibitor 1; Ppp1r1a; protein phosphatase 1 regulatory inhibitor subunit 1A; protein phosphatase 1 regulatory subunit 1A; protein phosphatase 1, regulatory (inhibitor) subunit 1A; protein phosphatase inhibitor 1; protein phosphatase inhibitor-1
• Gene Symbols: Ppp1r1a
• Host Species: Rabbit
• Immunogen: Recombinant protein corresponding to Human PPP1R1A. Recombinant protein control fragment (Product #RP-102910).
• Purification Method: Antigen affinity chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 5502
• Target Species: Human
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov