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Invitrogen™ PPP1R1A Polyclonal Antibody
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Catalog No. PIPA5102875
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PIPA5102875 100 μL
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Catalog No. PIPA5102875 Supplier Invitrogen™ Supplier No. PA5102875
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total PPP1R1A.

Protein phosphatase inhibitor-1 (also designated inhibitor of protein phospha-tase 1, IPP-1 and I-1) plays a role in regulating the phosphorylation of other proteins, and is itself phosphorylated by a cyclic AMP-dependent protein kinase at Threonine 35. In addition, the proline-directed kinases Cdk1, Cdk5, and mitogen-activated protein kinase (MAPK) mediate in vitro phosphorylation of IPP-1 at the phylogenetically conserved position Serine 67. In striatal tissues, glutamate-dependent regulation of N-methyl-d-aspartic acid-type channels influences IPP-1 phosphorylation at Ser 67. The localization and expression of IPP-1 suggests that it may play discrete roles in certain regions and developing stages of the brain, independent of the regulation of protein phosphatase type 1 (PP-1). PP-1 binds to both phosphorylated and dephosphorylated IPP-1. Conversion of PP-1 to a Mn++-dependent state appears to play a role in its regulation by IPP-1. IPP-1 attenuates the activity of glycogen phosphorylase and is thought to be important in the hormonal control of glycogen metabolism.
TRUSTED_SUSTAINABILITY

Specifications

Antigen PPP1R1A
Applications Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Ppp1r1a
Gene Accession No. Q13522
Gene Alias 0610038N18Rik; I1; I-1; inhibitor-1; Ipp1; IPP-1; PP1 inhibitor 1; Ppp1r1a; protein phosphatase 1 regulatory inhibitor subunit 1A; protein phosphatase 1 regulatory subunit 1A; protein phosphatase 1, regulatory (inhibitor) subunit 1A; protein phosphatase inhibitor 1; protein phosphatase inhibitor-1
Gene Symbols Ppp1r1a
Host Species Rabbit
Immunogen A synthesized peptide derived from human PPP1R1A(Accession Q13522), corresponding to amino acid residues G128-V171.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 5502
Target Species Human, Monkey
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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