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Invitrogen™ PPP1R8 Polyclonal Antibody
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Catalog No. PIPA5121027
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100 μL
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PIPA5121027 100 μL
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Catalog No. PIPA5121027 Supplier Invitrogen™ Supplier No. PA5121027
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Description

Rabbit Polyclonal Antibody

Positive test controls include: HL-60, PC-12, HeLa, HepG2, 293T, Mouse brain. The target is usually found in the following locations: Cytoplasm, Nucleus, Nucleus speckle. Immunogen sequence: MGGEDDELKG LLGLPEEETE LDNLTEFNTA HNKRISTLTI EEGNLDIQRP KRKRKNSRVT FSEDDEIINP EDVDPSVGRF RNMVQTAVVP VKKKRVEGPG SLGLEESGSR RMQNFAFSGG LYGGLPPTHS EAGSQPHGIH GTALIGGLPM PYPNLAPDVD LTPVVPSAVN MNPAPNPAVY NPEAVNEPKK KKYAKEAWPG KKPTPSLLI.

This gene, through alternative splicing, encodes three different isoforms. Two of the protein isoforms encoded by this gene are specific inhibitors of type 1 serine/threonine protein phosphatases and can bind but not cleave RNA. The third protein isoform lacks the phosphatase inhibitory function but is a single-strand endoribonuclease comparable to RNase E of E. coli. This isoform requires magnesium for its function and cleaves specific sites in A+U-rich regions of RNA.
TRUSTED_SUSTAINABILITY

Specifications

Antigen PPP1R8
Applications ELISA, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 0.38 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene PPP1R8
Gene Accession No. Q12972, Q8R3G1
Gene Alias 6330548N22Rik; activator of RNA decay; ARD1; ARD-1; AU044684; LOC100722083; NIPP1; NIPP-1; NIPP-1, nuclear inhibitor of protein phosphatase-1; Nuclear inhibitor of protein phosphatase 1; nuclear inhibitor of protein phosphatase-1 alpha; nuclear inhibitor of protein phosphatase-1 beta; nuclear subunit of PP-1; Ppp1r8; PRO2047; protein phosphatase 1 regulatory inhibitor subunit 8; protein phosphatase 1 regulatory subunit 8; protein phosphatase 1, regulatory (inhibitor) subunit 8; protein phosphatase 1, regulatory inhibitor subunit 8; protein phosphatase 1, regulatory subunit 8; RNase E
Gene Symbols PPP1R8
Host Species Rabbit
Immunogen Recombinant protein (or fragment).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 100336, 313030, 5511
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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