Invitrogen™ PPP2R2A/PPP2R2B Polyclonal Antibody

Catalog No.	Quantity
01-674-124	100 μg

Catalog No. 01-674-124 Supplier Invitrogen™ Supplier No. PA112391

Description

Sheep Polyclonal Antibody

PPP2R2A/PPP2R2B Polyclonal Antibody for Western Blot

The product of this gene belongs to the phosphatase 2 regulatory subunit B family. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a beta isoform of the regulatory subunit B55 subfamily. Defects in this gene cause autosomal dominant spinocerebellar ataxia 12 (SCA12), a disease caused by degeneration of the cerebellum, sometimes involving the brainstem and spinal cord, and in resulting in poor coordination of speech and body movements. Multiple alternatively spliced variants, which encode different isoforms, have been identified for this gene. The 5' UTR of some of these variants includes a CAG trinucleotide repeat sequence (7-28 copies) that can be expanded to 66-78 copies in cases of SCA12.

Specifications

• Antigen: PPP2R2A/PPP2R2B
• Applications: Western Blot
• Classification: Polyclonal
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 0.08% sodium azide
• Gene: PPP2R2A
• Gene Accession No.: P36876, P36877, P63151, Q00005, Q5E9Q7, Q6P1F6, Q6ZWR4
• Gene Alias: 2410004D02Rik; 2900026H06Rik; 6330404L05Rik; B55A; B55ALPHA; B55BETA; beta isoform of regulatory subunit B55, protein phosphatase 2 isoform a; BRbeta B-regulatory subunit of protein phosphatase 2A; E130009M08Rik; mKIAA1541; PP2A subunit B isoform alpha; PP2A subunit B isoform B55-alpha; PP2A subunit B isoform B55-beta; PP2A subunit B isoform beta; PP2A subunit B isoform BRA; PP2A subunit B isoform BRB; PP2A subunit B isoform PR55-alpha; PP2A subunit B isoform PR55-beta; PP2A subunit B isoform R2-alpha; PP2A subunit B isoform R2-beta; PP2A, subunit B, B55-alpha isoform; PP2A, subunit B, B55-beta isoform; PP2A, subunit B, B-alpha isoform; PP2A, subunit B, B-beta isoform; PP2A, subunit B, BRA isoform; PP2A, subunit B, BRB isoform; PP2A, subunit B, PR55-alpha isoform; PP2A, subunit B, PR55-beta isoform; PP2A, subunit B, R2-alpha isoform; PP2A, subunit B, R2-beta isoform; PP2AB55BETA; PP2ABBETA; PP2APR55B; PP2A-PR55B; PP2APR55BETA; PPP2R2A; Ppp2r2b; Pppr2b2; PR2AB55BETA; PR2ABBETA; PR2APR55BETA; PR52A; PR52B; PR55A; PR55BETA; PR55-BETA; protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), alpha isoform; protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), beta isoform; protein phosphatase 2 (formerly 2A), regulatory subunit B (PR52), alpha isoform; protein phosphatase 2 (formerly 2A), regulatory subunit B, alpha isoform; protein phosphatase 2 (formerly 2A), regulatory subunit B, beta isoform; protein phosphatase 2 regulatory subunit B, alpha; protein phosphatase 2 regulatory subunit B, beta; protein phosphatase 2 regulatory subunit Balpha; protein phosphatase 2 regulatory subunit Bbeta; protein phosphatase 2, regulatory subunit B, alpha; protein phosphatase 2, regulatory subunit B, beta; SCA12; serine/threonine protein phosphatase 2A, 55 KDA regulatory subunit B, alpha isoform; serine/threonine protein phosphatase 2A, 55 kDa regulatory subunit B, beta isoform; serine/threonine protein phosphatase 2A, neuronal isoform; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform; Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform; testicular tissue protein Li 156
• Gene Symbols: PPP2R2A, PPP2R2B
• Host Species: Sheep
• Immunogen: Purified peptide conjugated to KLH.
• Purification Method: Ammonium sulfate precipitation
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 117104, 508045, 509290, 5520, 5521, 60660, 71978, 72930
• Target Species: Human, Mouse, Rat, Bovine
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG