Invitrogen™ PPP6C Recombinant Rabbit Monoclonal Antibody (JE61-21)

Rabbit Recombinant Monoclonal Antibody

Supplier:  Invitrogen™ MA544864

Catalog No. PIMA544864

Description

PPP6C Recombinant Monoclonal Antibody for Western Blot, ICC/IF, IHC (P), Flow

Distinct DNA repair pathways minimize the consequences of mutagenic events. Reactive oxygen species (ROS) are highly reactive atoms with an unpaired electron that are conducive to double-strand DNA breaking events. Artemis, named after the Greek goddess for the protection of children, is one of the major proteins contributing to the preservation of double-strand breaks in DNA by cutting away the damaged parts of the DNA, which allows the strands to rejoin. Artemis is a single-strand-specific 5' to 3' exonuclease that forms a complex with the 469 kDa DNA-dependent protein kinase (DNA-PKcs). DNA-PKcs phosphorylates Artemis, and Artemis acquires endonucleolytic activity on 5' and 3' overhangs and hairpins. These activities are essential for V(D)J recombination and for the 5' and 3' overhang processing in nonhomologous DNA end joining.

Specifications

• Antigen: PPP6C
• Classification: Recombinant Monoclonal
• Concentration: 1 mg/mL
• Formulation: TBS with 0.05% BSA, 40% glycerol and 0.05% sodium azide; pH 7.4
• Gene Accession No.: O00743, Q9CQR6
• Gene Symbols: Ppp6c
• Immunogen: Synthetic peptide within human PPP6C aa 255-305/305.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG

• Applications: Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Clone: JE61-21
• Conjugate: Unconjugated
• Gene: Ppp6c
• Gene Alias: 2310003C10Rik; ANKRD33; FLJ34236; PP6; PP6C; PPP6; PPP6C; Ppv; PP-V; protein phosphatase 6 catalytic subunit; protein phosphatase 6, catalytic subunit; protein phosphatase V; serine/threonine protein phosphatase catalytic subunit; serine/threonine-protein phosphatase 6 catalytic subunit; Serine/threonine-protein phosphatase 6 catalytic subunit, N-terminally processed; UNQ5837
• Host Species: Rabbit
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 5537, 67857
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid