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Invitrogen™ PPY Monoclonal Antibody (2G5D12)
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Catalog No. PIMA517157
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100 μg
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Catalog No. Quantity
PIMA517157 100 μg
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Catalog No. PIMA517157 Supplier Invitrogen™ Supplier No. MA517157
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Description

Mouse Monoclonal Antibody

MA5-17157 targets PPY in FACS, indirect ELISA, and WB applications and shows reactivity with Human samples. The MA5-17157 immunogen is purified recombinant fragment of human PPY (amino acids: 1-95) expressed in E. Coli. MA5-17157 detects PPY which has a predicted molecular weight of approximately 10.4kDa.

The PPY gene encodes pancreatic polypeptide, a peptide hormone involved in the regulation of appetite and energy balance. The origin of the PPY gene is linked to a tandem duplication of the PYY gene, occurring concomitantly with the emergence of tetrapods, leading to the distinct PPY function within the neuropeptide Y family. In primates and ungulates, a gene duplication event resulted in the formation of a PYY2-PPY2 gene cluster, highlighting the evolutionary complexity of these genes. The PPY gene product is secreted by gamma-cells in the pancreas, localized primarily in the islet periphery, and plays a crucial role in metabolic homeostasis by interacting with receptors in the central nervous system to modulate satiety signals postprandially. PPY's function is linked to its inhibition of AGRP/NPY neurons which decreases their suppressive effect on POMC neurons, enhancing POMC activity and contributing to appetite suppression. This intricate regulation underscores the importance of PPY in dietary intake and metabolic disorders, with ongoing research exploring its potential therapeutic applications.
TRUSTED_SUSTAINABILITY

Specifications

Antigen PPY
Applications ELISA, Flow Cytometry, Western Blot
Classification Monoclonal
Clone 2G5D12
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.05% sodium azide
Gene PPY
Gene Accession No. P01298
Gene Alias AV061413; C-terminal peptide; HGNC:9327; IGSPP; IOPPP; Obinepitide; panceatic polypeptide; Pancreatic hormone; Pancreatic icosapeptide; Pancreatic polypeptide; pancreatic polypeptide Y; pancreatic prohormone; Pancreatic prohormone percursor; pancreatic prohormone precursor; PH; PI; PNP; PP; PP1; PPA1; PPase; Ppy; prepro-PP (prepropancreatic polypeptide); SID6-8061
Gene Symbols PPY
Host Species Mouse
Immunogen Purified recombinant fragment of human PPY (amino acids: 1-95) expressed in E. Coli.
Purification Method Protein G
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 5539
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG1
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