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Invitrogen™ PPY Monoclonal Antibody (6)
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Catalog No. 01670115
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400 μL
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Catalog No. Quantity
01-670-115 400 μL
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Catalog No. 01-670-115 Supplier Invitrogen™ Supplier No. ABS0300602
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Description

Mouse Monoclonal Antibody

ABS 030-06-02 detects PP in human samples. ABS 030-06-02 has been successfully used in ELISA procedures. NOTE: Concentration is lot-dependent and can vary from 0.85-1.15 mg/mL.

The PPY gene encodes pancreatic polypeptide, a peptide hormone involved in the regulation of appetite and energy balance. The origin of the PPY gene is linked to a tandem duplication of the PYY gene, occurring concomitantly with the emergence of tetrapods, leading to the distinct PPY function within the neuropeptide Y family. In primates and ungulates, a gene duplication event resulted in the formation of a PYY2-PPY2 gene cluster, highlighting the evolutionary complexity of these genes. The PPY gene product is secreted by gamma-cells in the pancreas, localized primarily in the islet periphery, and plays a crucial role in metabolic homeostasis by interacting with receptors in the central nervous system to modulate satiety signals postprandially. PPY's function is linked to its inhibition of AGRP/NPY neurons which decreases their suppressive effect on POMC neurons, enhancing POMC activity and contributing to appetite suppression. This intricate regulation underscores the importance of PPY in dietary intake and metabolic disorders, with ongoing research exploring its potential therapeutic applications.
TRUSTED_SUSTAINABILITY

Specifications

Antigen PPY
Applications ELISA, Western Blot
Classification Monoclonal
Clone 6
Concentration 0.92 mg/mL
Conjugate Unconjugated
Formulation PBS with 15mM sodium azide; pH 7.4
Gene PPY
Gene Accession No. P01298
Gene Alias AV061413; C-terminal peptide; HGNC:9327; IGSPP; IOPPP; Obinepitide; panceatic polypeptide; Pancreatic hormone; Pancreatic icosapeptide; Pancreatic polypeptide; pancreatic polypeptide Y; pancreatic prohormone; Pancreatic prohormone percursor; pancreatic prohormone precursor; PH; PI; PNP; PP; PP1; PPA1; PPase; Ppy; prepro-PP (prepropancreatic polypeptide); SID6-8061
Gene Symbols PPY
Host Species Mouse
Immunogen Synthetic peptide made to human PP.
Purification Method Protein A/G
Quantity 400 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 5539
Target Species Human
Content And Storage 4°C, store in dark
Product Type Antibody
Form Liquid
Isotype IgG1 κ
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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