Invitrogen™ PPY Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA578121

Catalog No. PIPA578121

Description

Positive Control: human PPY-transfected 293T cells Predicted Reactivity: Rhesus Monkey (100%) Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

The PPY gene encodes pancreatic polypeptide, a peptide hormone involved in the regulation of appetite and energy balance. The origin of the PPY gene is linked to a tandem duplication of the PYY gene, occurring concomitantly with the emergence of tetrapods, leading to the distinct PPY function within the neuropeptide Y family. In primates and ungulates, a gene duplication event resulted in the formation of a PYY2-PPY2 gene cluster, highlighting the evolutionary complexity of these genes. The PPY gene product is secreted by gamma-cells in the pancreas, localized primarily in the islet periphery, and plays a crucial role in metabolic homeostasis by interacting with receptors in the central nervous system to modulate satiety signals postprandially. PPY's function is linked to its inhibition of AGRP/NPY neurons which decreases their suppressive effect on POMC neurons, enhancing POMC activity and contributing to appetite suppression. This intricate regulation underscores the importance of PPY in dietary intake and metabolic disorders, with ongoing research exploring its potential therapeutic applications.

Specifications

• Antigen: PPY
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: PPY
• Gene Alias: AV061413; C-terminal peptide; HGNC:9327; IGSPP; IOPPP; Obinepitide; panceatic polypeptide; Pancreatic hormone; Pancreatic icosapeptide; Pancreatic polypeptide; pancreatic polypeptide Y; pancreatic prohormone; Pancreatic prohormone percursor; pancreatic prohormone precursor; PH; PI; PNP; PP; PP1; PPA1; PPase; Ppy; prepro-PP (prepropancreatic polypeptide); SID6-8061
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 5539
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 20% glycerol and 0.01% thimerosal; pH 7
• Gene Accession No.: P01298
• Gene Symbols: PPY
• Immunogen: Carrier-protein conjugated synthetic peptide encompassing a sequence within the center region of human Pancreatic polypeptide. The exact sequence is proprietary.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG