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Invitrogen™ PR3 Monoclonal Antibody (3B4)
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Catalog No. PIMA515540
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100 μL
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Catalog No. Quantity
PIMA515540 100 μL
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Catalog No. PIMA515540 Supplier Invitrogen™ Supplier No. MA515540
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Description

Mouse Monoclonal Antibody

MA5-15540 targets Proteinase 3 in indirect ELISA, WB applications and shows reactivity with Human samples. The MA5-15540 immunogen is purified recombinant fragment of human Proteinase 3 expressed in E. Coli. MA5-15540 detects Proteinase 3 which has a predicted molecular weight of approximately 28kDa.

Serine protease that degrades elastin, fibronectin, laminin, vitronectin, and collagen types I, III, and IV (in vitro) (PubMed:3198760, PubMed:2033050, PubMed:28240246). By cleaving and activating receptor F2RL1/PAR-2, enhances endothelial cell barrier function and thus vascular integrity during neutrophil transendothelial migration (PubMed:23202369). May play a role in neutrophil transendothelial migration, probably when associated with CD177 (PubMed:22266279). [UniProt].
TRUSTED_SUSTAINABILITY

Specifications

Antigen PR3
Applications ELISA, Western Blot
Classification Monoclonal
Clone 3B4
Concentration Conc. Not Determined
Conjugate Unconjugated
Formulation ascites with 0.03% sodium azide
Gene PRTN3
Gene Accession No. P24158
Gene Alias ACPA; AGP7; azurophil granule protein 7; CANCA; C-ANCA; C-ANCA antigen; leukocyte proteinase 3; MBN; MBT; mPR3; Myeloblastin; neutrophil proteinase 4; NP4; NP-4; P29; PR3; PR-3; Proteinase 3; PRTN3; serine proteinase, neutrophil; wegener autoantigen; Wegener granulomatosis autoantigen
Gene Symbols PRTN3
Host Species Mouse
Immunogen Purified recombinant fragment of human Proteinase 3 expressed in E. Coli.
Purification Method Protein G
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 5657
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG2b
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