PR3 Monoclonal Antibody (MCPR3-2), Invitrogen™

Mouse Monoclonal Antibody

Supplier:  Thermo Scientific MA511945

Catalog No. PIMA511945

Description

MA5-11945 targets Proteinase 3 in IF, FACS and WB applications and shows reactivity with mouse and human samples. The MA5-11945 immunogen is hMC-1/PR3 cell granule extract.

Serine protease that degrades elastin, fibronectin, laminin, vitronectin, and collagen types I, III, and IV (in vitro) (PubMed:3198760, PubMed:2033050, PubMed:28240246). By cleaving and activating receptor F2RL1/PAR-2, enhances endothelial cell barrier function and thus vascular integrity during neutrophil transendothelial migration (PubMed:23202369). May play a role in neutrophil transendothelial migration, probably when associated with CD177 (PubMed:22266279). [UniProt]

Specifications

• Antigen: PR3
• Classification: Monoclonal
• Concentration: 0.2 mg/mL
• Formulation: PBS with 0.2% BSA and 0.09% sodium azide; pH 7.4
• Gene Accession No.: P24158, Q61096
• Gene Symbols: PRTN3
• Immunogen: HMC-1/PR3 cell granule extract
• Quantity: 500 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG1 κ

• Applications: Flow Cytometry, Immunocytochemistry, Western Blot
• Clone: MCPR3-2
• Conjugate: Unconjugated
• Gene: PRTN3
• Gene Alias: ACPA; AGP7; azurophil granule protein 7; CANCA; C-ANCA; C-ANCA antigen; leukocyte proteinase 3; MBN; MBT; mPR3; Myeloblastin; neutrophil proteinase 4; NP4; NP-4; P29; PR3; PR-3; Proteinase 3; PRTN3; serine proteinase, neutrophil; wegener autoantigen; Wegener granulomatosis autoantigen
• Host Species: Mouse
• Purification Method: Protein G
• Regulatory Status: RUO
• Gene ID (Entrez): 19152, 5657
• Content And Storage: 4° C
• Form: Liquid