Invitrogen™ PRAK Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA528616

Catalog No. PIPA528616

Description

Recommended positive controls: HepG2. Predicted reactivity: Mouse (98%), Rat (96%), Zebrafish (92%), Pig (98%), Chicken (97%), Rhesus Monkey (99%), Bovine (97%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

MAPKAPK5 (PRAK) is activated in response to cellular stress and pro-inflammatory cytokines. Activity of this kinase is regulated by p38 alpha and p38 beta. The protein encoded by PRAK is a member of the serine/threonine kinase family. In response to cellular stress and proinflammatory cytokines, this kinase is activated through its phosphorylation by MAP kinases including MAPK1/ERK, MAPK14/p38-alpha, and MAPK11/p38-beta. In vitro, this kinase phosphorylates heat shock protein HSP27 at its physiologically relevant sites. Two alternately spliced transcript variants of PRAK encoding distinct isoforms have been reported.

Specifications

• Antigen: PRAK
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: MAPKAPK5
• Gene Alias: MAP kinase-activated protein kinase 5; MAPK-activated protein kinase 5; MAPKAP kinase 5; Mapkapk5; MAPKAP-K5; MAPKAPK-5; mitogen-activated protein kinase-activated protein kinase 5; MK5; MK-5; p38-regulated/activated protein kinase; PRAK
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 8550
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Western Blot
• Concentration: 0.62 mg/mL
• Formulation: 0.1M tris glycine with 10% glycerol and 0.01% thimerosal; pH 7
• Gene Accession No.: Q8IW41
• Gene Symbols: MAPKAPK5
• Immunogen: Recombinant fragment corresponding to a region within amino acids 1 and 256 of Human PRAK.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov