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Invitrogen™ PRAS40 Polyclonal Antibody
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Catalog No. PIPA531178
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100 μL
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PIPA531178 100 μL
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Catalog No. PIPA531178 Supplier Invitrogen™ Supplier No. PA531178
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Description

Rabbit Polyclonal Antibody

Recommended positive controls: 293T, A431, HeLa, Neuro2A, C8D30, NIH-3T3, Raw264.7, C2C12. Predicted reactivity: Mouse (94%), Rat (92%), Chimpanzee (99%), Bovine (95%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

The Akt signaling pathway contributes to the regulation of apoptosis after a variety of cell death signals. AKT1S1, also known as PRAS40, is a proline-rich substrate of the kinase AKT1 and is thought to play a role in neuroprotection mediated by nerve growth factor (NGF) after transient focal cerebral ischemia. AKT1S1 is also a substrate and potential regulator of mammalian target of rapamycin (mTOR), a serine/threonine kinase that regulates cell growth and cell cycle, and a negative regulator of autophagy. Treatment with the insulin-like growth factor-1 (IGF1) can induce the phosphorylation of AKT1S1 via the PI3K/AKT signaling pathway in PC12 cells.
TRUSTED_SUSTAINABILITY

Specifications

Antigen PRAS40
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 20% glycerol and 0.01% thimerosal; pH 7
Gene AKT1S1
Gene Accession No. Q96B36, Q9D1F4
Gene Alias 1110012J22Rik; 40 kDa proline-rich AKT substrate; AI227026; AKT1 substrate 1; AKT1 substrate 1 (proline rich); AKT1 substrate 1 (proline-rich); akt1s1; Lobe; Lobel; OTTHUMP00000196756; OTTHUMP00000196760; PKB/Akt substrate 40; Pras; PRAS40; Proline-rich AKT substrate; proline-rich AKT1 substrate 1
Gene Symbols AKT1S1
Host Species Rabbit
Immunogen Recombinant protein encompassing a sequence within the center region of human PRAS40. The exact sequence is proprietary.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 292887, 67605, 84335
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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