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Invitrogen™ PRDM16 Polyclonal Antibody
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Catalog No. PIPA5142015
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100 μg
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PIPA5142015 100 μg
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Catalog No. PIPA5142015 Supplier Invitrogen™ Supplier No. PA5142015
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Description

Goat Polyclonal Antibody

Additional Information: This antibody is expected to recognise both reported isoforms. This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:32,000.

PRDM16 is a zinc finger transcription factor and contains an N-terminal PR domain. The reciprocal translocation t(1;3)(p36;q21) occurs in a subset of myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). This gene is located near the 1p36.3 breakpoint and has been shown to be specifically expressed in the t(1:3)(p36, q21)-positive MDS/AML. The translocation results in the overexpression of a truncated version of this protein that lacks the PR domain, which may play an important role in the pathogenesis of MDS and AML. Recent studies have shown that PRDM16 normally acts as a Smad3 binding protein that may be important for the development of orofacial structures through modulation of the TGF-beta signaling pathway. Other experiments have indicated that PRDM16 controls a bidirectional cell fate switch between skeletal myoblasts and brown fat cells.
TRUSTED_SUSTAINABILITY

Specifications

Antigen PRDM16
Applications ChIP Assay, Flow Cytometry
Classification Polyclonal
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation TBS with 0.5% BSA and 0.02% sodium azide; pH 7.3
Gene PRDM16
Gene Accession No. A2A935, Q9HAZ2
Gene Alias 5730557K01Rik; CMD1LL; csp1; Histone-lysine N-methyltransferase PRDM16; Kiaa1675; line 27; LVNC8; MDS1/EVI1-like gene 1; MEL1; PFM13; PR domain 16; PR domain containing 16; PR domain zinc finger protein 16; PR domain-containing protein 16; Prdm16; Transcription factor MEL1
Gene Symbols PRDM16
Host Species Goat
Immunogen Peptide with sequence C-TSESGAFHPINHL.
Purification Method Ammonium sulfate precipitation
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 63976, 70673
Target Species Human, Mouse
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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