Invitrogen™ PRDM16 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ 720206

Catalog No. PI720206

Description

This antibody is predicted to react with Monkey, Mouse, Dog.

PRDM16 is a zinc finger transcription factor and contains an N-terminal PR domain. The reciprocal translocation t(1;3)(p36;q21) occurs in a subset of myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). This gene is located near the 1p36.3 breakpoint and has been shown to be specifically expressed in the t(1:3)(p36, q21)-positive MDS/AML. The translocation results in the overexpression of a truncated version of this protein that lacks the PR domain, which may play an important role in the pathogenesis of MDS and AML. Recent studies have shown that PRDM16 normally acts as a Smad3 binding protein that may be important for the development of orofacial structures through modulation of the TGF-beta signaling pathway. Other experiments have indicated that PRDM16 controls a bidirectional cell fate switch between skeletal myoblasts and brown fat cells.

Specifications

• Antigen: PRDM16
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: PRDM16
• Gene Alias: 5730557K01Rik; CMD1LL; csp1; Histone-lysine N-methyltransferase PRDM16; Kiaa1675; line 27; LVNC8; MDS1/EVI1-like gene 1; MEL1; PFM13; PR domain 16; PR domain containing 16; PR domain zinc finger protein 16; PR domain-containing protein 16; Prdm16; Transcription factor MEL1
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 100366024, 63976, 70673
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Western Blot
• Concentration: 0.5 mg/mL
• Formulation: PBS with 0.1% BSA, 30% glycerol and 0.09% sodium azide; pH 7.4
• Gene Accession No.: A2A935, Q9HAZ2
• Gene Symbols: PRDM16
• Immunogen: Peptides corresponding to human PRDM16/MEL1 (236-251, 23-40).
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG