Invitrogen™ PRDM2 Monoclonal Antibody (33AT1045)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA511144

Catalog No. PIMA511144

Description

This antibody is specific for RIZ1, it does not recognize the isoform beta (RIZ2).

PRDM2, a member of nuclear/histone methyltransferase superfamily, consists of an N-terminal PR domain, an Rb-binding motif, 8 Kruppel-like zinc finger motifs, Nuclear hormone-receptor binding motif and a C-terminal PR-domain binding motif. Ubiquitously expressed in low levels, PRDM2 exists in 2 isoforms, a 280 kDa RIZ1 containing PR-domain and a 250 kDa truncated RIZ2 that lacks PR-domain. A tumor suppressor with a prominent role in cell growth and differentiation, PRDM2 binds to Retinoblastoma protein, estrogen receptor, GATA-3 and TPA-responsive element (MTE) of Heme-oxygenase-1 gene and influences pathogenesis of Retinoblastoma, transcriptional regulation during neuronal differentiation, transactivation of Heme-oxygenase-1 gene and specific effector of estrogen action. It is inactivated or altered due to mutations and hypermethylation in many types of human cancers suggesting a potential biomarker.

Specifications

• Antigen: PRDM2
• Classification: Monoclonal
• Concentration: 0.5 mg/mL
• Formulation: PBS with 0.09% sodium azide; pH 7.4
• Gene Accession No.: Q13029
• Gene Symbols: PRDM2
• Immunogen: Purified recombinant GST fusion protein encoding aa 1-347 of human RIZ1.
• Quantity: 400 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG1

• Applications: ChIP Assay, Western Blot
• Clone: 33AT1045
• Conjugate: Unconjugated
• Gene: PRDM2
• Gene Alias: 4833427P12Rik; E330024L24Rik; G3b; GATA-3 binding protein G3B; GATA-3-binding protein G3B; Gm1033; Gm19732; HUMHOXY1; KMT8; lysine N-methyltransferase 8; MTBzf; MTB-ZF; MTE-binding protein; PR domain 2; PR domain containing 2, with ZNF domain; PR domain zinc finger protein 2; PR domain-containing protein 2; Prdm2; retinoblastoma interacting zinc finger protein; retinoblastoma protein-binding zinc finger protein; retinoblastoma protein-interacting zinc finger protein; RIZ; RIZ1; RIZ2; RP5-1177E19.1; zinc finger protein RIZ; zinc-finger DNA-binding protein; Znfpr1c1
• Host Species: Mouse
• Purification Method: Protein G
• Regulatory Status: RUO
• Gene ID (Entrez): 110593, 7799
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid