Invitrogen™ PRDX6 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA524632

Catalog No. PIPA524632

Description

This antibody is predicted to react with bovine, non-human primate and rat based on sequence homology.

Peroxiredoxin (Prx) is a growing peroxidase family, whose mammalian members have been known to connect with cell proliferation, differentiation, and apoptosis. Many isoforms (about 50 proteins), collected in accordance to the amino acid sequence homology, containing active site cysteine residue, and the thiol-specific antioxidant activity, distribute throughout all the kingdoms. Among them, mammalian Prx consists of 6 different members grouped into typical 2-Cys, atypical 2-Cys Prx, and 1-Cys Prx. Except Prx VI belonging to 1-Cys Prx subgroup, the other five 2-Cys Prx isotypes have the thioredoxin-dependent peroxidase (TPx) activity utilizing thioredoxin, thioredoxin reductase, and NADPH as a reducing system. Mammalian Prxs are 20-30 kilodalton in molecular size and vary in subcellular localization: Prx I, II, and VI in cytosol, Prx III in mitochondria, Prx IV in ER and secretion, Prx V showing complicated distribution including peroxisome, mitochondria and cytosol.

Specifications

• Antigen: PRDX6
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: PRDX6
• Gene Alias: 1-Cys; 1-Cys peroxiredoxin; 1-Cys PRX; 1-cysPrx; 24 kDa protein; 9430088D19Rik; AA690119; Acidic calcium-independent phospholipase A2; aiPLA2; Antioxidant protein 2; Aop2; Brp-12; CP-3; epididymis secretory sperm binding protein Li 128m; GPx; HEL-S-128m; KIAA0106; Liver 2D page spot 40; Ltw4; Ltw-4; Lvtw-4; MGC46173; MSP23; NKEFA; Non-selenium glutathione peroxidase; NSGPx; ORF06; p29; PAG; PAGA; PAGB; peroxiredoxin 6; peroxiredoxin-6; Prdx5; Prdx6; PRX; Prx6; Red blood cells page spot 12; thiol-specific antioxidant protein; Tsa
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography, Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 9588
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.4 mg/mL
• Formulation: PBS with 0.09% sodium azide; pH 7.4
• Gene Accession No.: P30041
• Gene Symbols: PRDX6
• Immunogen: KLH conjugated synthetic peptide between 103-132 amino acids from the central region of human PRDX6.
• Quantity: 400 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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