Invitrogen™ PREB Polyclonal Antibody

Catalog No.	Quantity
PIPA553066	100 μL

Catalog No. PIPA553066 Supplier Invitrogen™ Supplier No. PA553066

Description

Rabbit Polyclonal Antibody

Immunogen sequence: REAHGIVVTD VAFLPEKGRG PELLGSHETA LFSVAVDSRC QLHLLPSRRS VP Highest antigen sequence identity to the following orthologs: Mouse - 90%, Rat - 90%.

Prolactin (PRL) expression in the pituitary is limited to specific cells. Pit-1 is a pituitary specific transcription factor that plays an important role in PRL expression, both in mature organism and during development. The PRL promoter contains numerous Pit-1 binding sites and these sites have been implicated in both basal level and kinase-mediated gene expression. The most proximal of these binding sites, termed 1P, has been shown to direct a response to numerous signals, such as cAMP and various G-proteins. A novel protein, termed PREB (prolactin regulatory element binding protein), has been recently identified that regulates PRL gene expression through the 1P site, though it contains no discernable DNA-binding motif. Recent studies suggest that PREB is encoded by a single-copy gene in both mice and humans and exhibits nuclear accumulation in pituitary cells. Evidence suggests that PREB is a novel transcription factor that assists in PRL expression whether alone, or in concert with Pit-1.

Specifications

• Antigen: PREB
• Applications: Immunohistochemistry (Paraffin), Western Blot
• Classification: Polyclonal
• Concentration: 0.1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene: Preb
• Gene Accession No.: Q9HCU5, Q9WTV0, Q9WUQ2
• Gene Alias: C85705; mammalian guanine nucleotide exchange factor mSec12; PREB; prolactin regulatory binding-element protein; prolactin regulatory element binding; prolactin regulatory element binding protein; prolactin regulatory element-binding protein; Sec12
• Gene Symbols: Preb
• Host Species: Rabbit
• Immunogen: Recombinant protein corresponding to Human PREB. Recombinant protein control fragment (Product #RP-90969).
• Purification Method: Antigen affinity chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 10113, 50907, 58842
• Target Species: Human, Mouse, Rat
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov