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PREB Rabbit anti-Human, Mouse, Polyclonal, Proteintech

Rabbit Polyclonal Antibody




Antigen PREB
Concentration 0.39 mg/mL
Applications Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Conjugate Unconjugated
Format Liquid
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Catalog Number Mfr. No. Quantity Price Quantity & Availability  
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Proteintech Group IncSupplier Diversity Partner
150 μL
Each for $395.30
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Prolactin (PRL) expression in the pituitary is limited to specific cells. Pit-1 is a pituitary specific transcription factor that plays an important role in PRL expression, both in mature organism and during development. The PRL promoter contains numerous Pit-1 binding sites and these sites have been implicated in both basal level and kinase-mediated gene expression. The most proximal of these binding sites, termed 1P, has been shown to direct a response to numerous signals, such as cAMP and various G-proteins. A novel protein, termed PREB (prolactin regulatory element binding protein), has been recently identified that regulates PRL gene expression through the 1P site, though it contains no discernable DNA-binding motif. Recent studies suggest that PREB is encoded by a single-copy gene in both mice and humans and exhibits nuclear accumulation in pituitary cells. Evidence suggests that PREB is a novel transcription factor that assists in PRL expression whether alone, or in concert with Pit-1.


Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
0.39 mg/mL
Human, Mouse
Antigen Affinity Chromatography
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