Invitrogen™ Precerebellin Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA520159

Catalog No. PIPA520159

Description

A suggested positive control is 293 cell lysate. PA5-20159 can be used with blocking peptide PEP-0278.

Precerebellin is the precursor of the brain-specific hexadecapeptide cerebellin, a protein with substantial similarity to the globular region of the B chain of complement component C1q. Cerebellin exerts neuromodulatory functions by directly stimulating norepinephrine release via the adenylate cyclase/pka- dependent signaling pathway; and indirectly enhances adrenocortical secretion in vivo, through a paracrine mechanism involving medullary catecholamine release. The active form of precerebellin is highly enriched in postsynaptic structures of cerebellar Purkinje cells in cartwheel neurons of the dorsal cochlear nucleus. Because precerebellin belongs to the C1q/tumor necrosis factor superfamily of secreted proteins and has similarity to adiponectin and CTRP3, it has been suggested that precerebellin posseses functions other than those already stated.

Specifications

• Antigen: Precerebellin
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: CBLN1
• Gene Alias: [des-Ser1]CER; [des-Ser1]-cerebellin; AI323299; Brain protein D3; Cbln1; CER; Cerebellin; cerebellin 1 precursor; cerebellin 1 precursor protein; cerebellin-1; des-Ser(1)-cerebellin; des-Ser1-cerebellin; Precerebellin
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 12404, 498922, 869
• Content And Storage: Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
• Form: Liquid

• Applications: Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 0.02% sodium azide
• Gene Accession No.: P23435, P63182, Q9R171
• Gene Symbols: CBLN1
• Immunogen: A 16 amino acid synthetic peptide from near the carboxy-terminus human precerebellin.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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