Pref-1/DLK1/FA1 Rabbit anti-Mouse, PE, Clone: 1168B, R&D Systems™

Recombinant Monoclonal Antibody

Manufacturer:  R&D Systems FAB8634P100

Catalog No. FAB8634P100

Description

Pref-1 (Preadipocyte factor 1), also known as Protein delta homolog 1, DLK1, FA1 and Fetal antigen 1, is a 45-60kDa transmembrane glycoprotein that is highly expressed in fetal liver, placenta, adult adrenal gland, brain, testis and ovary. Expression of Pref-1 is elevated in liver after birth but starts to decline around postnatal day 16. Mature mouse Pref-1 is a 362 amino acid (aa) type I transmembrane N- and O-linked glycoprotein. It contains a 282 aa extracellular region (aa 24-305), a 24 aa transmembrane segment (aa 306-329), and a 56 aa cytoplasmic domain (aa 330-385). It contains 6 EGF-like domains and is involved in embryonic skeletal system development. Pref-1 inhibits preadipocyte proliferation by regulating their entry into G1/S-phase and represses preadipocyte differentiation. It is a master regulator of preadipocyte homeostasis and adipose tissue expansion. Pref-1 manipulation may, therefore, be utilized in obesity treatments. Mouse Pref-1 shares 85% and 94% aa identity with human and rat Pref-1, respectively.

Specifications

• Antigen: Pref-1/DLK1/FA1
• Clone: 1168B
• Dilution: Flow Cytometry 10 uL/10^6 cells
• Gene Accession No.: Q09163
• Gene Alias: delta-like 1 homolog (Drosophila), DLK, DLK1, DLK-1, FA1, FA1fetal antigen 1, pG2, pG2delta-like homolog (Drosophila), preadipocyte factor 1, Pref-1, PREF1, protein delta homolog 1, secredeltin, ZOG
• Host Species: Rabbit
• Isotype: IgG
• Quantity: 100 Tests
• Storage Requirements: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 degreesC as supplied.
• Monoclonal or Polyclonal: Monoclonal
• Test Specificity: Detects mouse Pref-1/DLK1/FA1 in direct ELISAs.

• Applications: Flow Cytometry
• Conjugate: R-PE
• Formulation: Supplied in a saline solution containing BSA and Sodium Azide. with Sodium Azide
• Format: Purified
• Gene Symbols: DLK1
• Immunogen: Mouse myeloma cell line NS0-derived recombinant mouse Pref-1/DLK1/FA1 Ala24-Gln305 Accession # Q09163
• Purification Method: Protein A or G purified from cell culture supernatant
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 8788
• Target Species: Mouse