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Presenilin-2 Rabbit anti-Human, Polyclonal, Bethyl Laboratories

Catalog No. 501567473
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50-156-7473 100 μL
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Catalog No. 50-156-7473 Supplier Bethyl Laboratories, Inc Supplier No. A304342A
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Description

Rabbit Polyclonal Antibody

The recommended shelf life for this product is 1 year from date of receipt. Application Note: For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections. Based on 100% sequence identity, this antibody is predicted to react with Mouse, Rat, Bovine, Pig and Orangutan

Familial Alzheimer′s disease is often characterized by an early (<60 years of age) and rapid deterioration of the central nervous system. The symptoms are caused by the abnormal buildup of senile plaques composed of the 42 residue amyloid-beta peptide. This peptide is the result of the amyloid precursor protein being cleaved by the presenilin-gamma-secretase complex. Recent studies have linked mutations in presenilin 1 (PS1) and presenilin 2 (PS2) to a rapid increase in plaque accumulation. PS1 and PS2 are integral membrane proteins that contain 6-8 transmembrane domains and are predomitly localized within the endoplasmic reticulum and Golgi of neurons within the brain. Within the transmembrane regions of PS1 and PS2 there is over 60% homology, with the largest divergence found at the N-terminus and large loop region.

Specifications

Antigen Presenilin-2
Applications Immunohistochemistry, Immunoprecipitation, Western Blot
Classification Polyclonal
Concentration 1 mg/ml
Conjugate Unconjugated
Formulation phosphate, tris citrate with 0.09% sodium azide; pH 7-8
Gene PSEN2
Gene Accession No. P49810
Gene Alias PS2, AD4, Alzheimer disease 4, PS2, PSEN 2, STM2
Gene Symbols PSEN2
Host Species Rabbit
Immunogen Between 275 and 325
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 5664
Target Species Human
Content And Storage 4° C
Product Type Antibody
Form Liquid
Isotype IgG
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