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Presenilin-2 Rabbit anti-Human, Polyclonal, Bethyl Laboratories
Rabbit Polyclonal Antibody
Supplier: Bethyl Laboratories, Inc A304342A

Description
The recommended shelf life for this product is 1 year from date of receipt. Application Note: For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections. Based on 100% sequence identity, this antibody is predicted to react with Mouse, Rat, Bovine, Pig and Orangutan
Familial Alzheimer′s disease is often characterized by an early (<60 years of age) and rapid deterioration of the central nervous system. The symptoms are caused by the abnormal buildup of senile plaques composed of the 42 residue amyloid-beta peptide. This peptide is the result of the amyloid precursor protein being cleaved by the presenilin-gamma-secretase complex. Recent studies have linked mutations in presenilin 1 (PS1) and presenilin 2 (PS2) to a rapid increase in plaque accumulation. PS1 and PS2 are integral membrane proteins that contain 6-8 transmembrane domains and are predomitly localized within the endoplasmic reticulum and Golgi of neurons within the brain. Within the transmembrane regions of PS1 and PS2 there is over 60% homology, with the largest divergence found at the N-terminus and large loop region.Specifications
Presenilin-2 | |
Polyclonal | |
Unconjugated | |
PSEN2 | |
PS2, AD4, Alzheimer disease 4, PS2, PSEN 2, STM2 | |
Rabbit | |
Antigen affinity chromatography | |
RUO | |
5664 | |
4° C | |
Liquid |
Immunohistochemistry, Immunoprecipitation, Western Blot | |
1 mg/ml | |
phosphate, tris citrate with 0.09% sodium azide; pH 7-8 | |
P49810 | |
PSEN2 | |
Between 275 and 325 | |
100 μL | |
Primary | |
Human | |
Antibody | |
IgG |
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