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Presenilin-2 Rabbit anti-Human, Polyclonal, Bethyl Laboratories

Rabbit Polyclonal Antibody

Supplier:  Bethyl Laboratories, Inc A304342A

Encompass_Preferred

Catalog No. 50-156-7473


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Description

Description

The recommended shelf life for this product is 1 year from date of receipt. Application Note: For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections. Based on 100% sequence identity, this antibody is predicted to react with Mouse, Rat, Bovine, Pig and Orangutan

Familial Alzheimer′s disease is often characterized by an early (<60 years of age) and rapid deterioration of the central nervous system. The symptoms are caused by the abnormal buildup of senile plaques composed of the 42 residue amyloid-beta peptide. This peptide is the result of the amyloid precursor protein being cleaved by the presenilin-gamma-secretase complex. Recent studies have linked mutations in presenilin 1 (PS1) and presenilin 2 (PS2) to a rapid increase in plaque accumulation. PS1 and PS2 are integral membrane proteins that contain 6-8 transmembrane domains and are predomitly localized within the endoplasmic reticulum and Golgi of neurons within the brain. Within the transmembrane regions of PS1 and PS2 there is over 60% homology, with the largest divergence found at the N-terminus and large loop region.
Specifications

Specifications

Presenilin-2
Polyclonal
Unconjugated
PSEN2
PS2, AD4, Alzheimer disease 4, PS2, PSEN 2, STM2
Rabbit
Antigen affinity chromatography
RUO
5664
4° C
Liquid
Immunohistochemistry, Immunoprecipitation, Western Blot
1 mg/ml
phosphate, tris citrate with 0.09% sodium azide; pH 7-8
P49810
PSEN2
Between 275 and 325
100 μL
Primary
Human
Antibody
IgG
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