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presenilin 2/PS-2 Rabbit anti-Human, Polyclonal, Bioss
SDP

Catalog No. 501985677
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50-198-5677 100 μL
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Catalog No. 50-198-5677 Supplier Bioss Supplier No. BS3815R
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Description

Rabbit Polyclonal Antibody

Alzheimer′s disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1 or PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor such that, they either directly regulate gamma-secretase activity, or themselves act are protease enzymes. Two alternatively spliced transcript variants encoding different isoforms of PSEN2 have been identified.

Specifications

Antigen presenilin 2/PS-2
Applications Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 μg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
Gene PSEN2
Gene Accession No. P49810
Gene Alias AD3L; AD3LP; AD4; Ad4h; AD5; Alg3; ALG-3; Alzheimer disease 4; CMD1V; E5-1; presenilin 2; Presenilin-2; Presenilin-2 CTF subunit; Presenilin-2 NTF subunit; PS2; Ps-2; PSEN 2; PSEN2; PSNL2; STM2; STM-2
Gene Symbols PSEN2
Host Species Rabbit
Immunogen KLH conjugated synthetic peptide derived from human presenilin 2/PS-2.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 5664
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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