PRKAR2A Mouse anti-Human, Clone: OTI1F8, lyophilized, TrueMAB™

Mouse Monoclonal Antibody

Supplier:  OriGene CF501146

Catalog No. 50-166-0180

Description

Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO

cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase (AMPK), which transduces the signal through phosphorylation of different target proteins. The inactive holoenzyme of AMPK is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits of AMPK have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. It may interact with various A-kinase anchoring proteins and determine the subcellular localization of AMPK.

Specifications

• Antigen: PRKAR2A
• Classification: Monoclonal
• Conjugate: Unconjugated
• Gene: PRKAR2A
• Gene Alias: PKR2, PRKAR2
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 5576
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized

• Applications: Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
• Clone: OTI1F8
• Formulation: PBS with 8% trehalose and no preservative; pH 7.3
• Gene Accession No.: P13861
• Gene Symbols: PRKAR2A
• Immunogen: Full length human recombit protein of human PRKAR2A produced in HEK293T cell.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1