Invitrogen™ PRKAR2B Polyclonal Antibody

Catalog No.	Quantity
PIPA513799	400 μL

Catalog No. PIPA513799 Supplier Invitrogen™ Supplier No. PA513799

Description

Rabbit Polyclonal Antibody

PRKAR2B Polyclonal Antibody for Western Blot

cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. This subunit has been shown to interact with and suppress the transcriptional activity of the cAMP responsive element binding protein 1 (CREB1) in activated T cells. Knockout studies in mice suggest that this subunit may play an important role in regulating energy balance and adiposity. The studies also suggest that this subunit may mediate the gene induction and cataleptic behavior induced by haloperidol.

Specifications

• Antigen: PRKAR2B
• Applications: Western Blot
• Classification: Polyclonal
• Concentration: 2 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 0.09% sodium azide; pH 7.4
• Gene: Prkar2b
• Gene Accession No.: P31323, P31324
• Gene Alias: AI451071; AW061005; cAMP-dependent protein kinase RII-beta regulatory subunit; cAMP-dependent protein kinase type II-beta regulatory chain; cAMP-dependent protein kinase type II-beta regulatory subunit; H_RG363E19.2; Pkarb2; PKARIIbeta; PRKAR2; PRKAR2B; protein kinase cAMP-dependent type II regulatory subunit beta; protein kinase, cAMP dependent regulatory, type II beta; protein kinase, cAMP-dependent, regulatory subunit type II beta; protein kinase, cAMP-dependent, regulatory, type II, beta; RATDNA; RII(beta); RII-BETA; Type II beta regulatory subunit of cAMP-dependent protein kinase; WUGSC:H_RG363E19.2
• Gene Symbols: Prkar2b
• Host Species: Rabbit
• Immunogen: KLH conjugated synthetic peptide between 32-62 amino acids from the N-terminal region of human PKA 2 beta (PRKAR2B).
• Purification Method: Antigen affinity chromatography
• Quantity: 400 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 19088, 5577
• Target Species: Human, Mouse
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG