Invitrogen™ PRKAR2B Recombinant Rabbit Monoclonal Antibody (JA11-69)

Catalog No.	Quantity
PIMA532662	100 μL

Catalog No. PIMA532662 Supplier Invitrogen™ Supplier No. MA532662

Description

Rabbit Recombinant Monoclonal Antibody

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.

cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. This subunit has been shown to interact with and suppress the transcriptional activity of the cAMP responsive element binding protein 1 (CREB1) in activated T cells. Knockout studies in mice suggest that this subunit may play an important role in regulating energy balance and adiposity. The studies also suggest that this subunit may mediate the gene induction and cataleptic behavior induced by haloperidol.

Specifications

• Antigen: PRKAR2B
• Applications: Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry, Western Blot
• Classification: Recombinant Monoclonal
• Clone: JA11-69
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: TBS with 0.05% BSA, 40% Glycerol and 0.05% sodium azide; pH 7.4
• Gene: Prkar2b
• Gene Accession No.: P12369, P31323, P31324
• Gene Alias: AI451071; AW061005; cAMP-dependent protein kinase RII-beta regulatory subunit; cAMP-dependent protein kinase type II-beta regulatory chain; cAMP-dependent protein kinase type II-beta regulatory subunit; H_RG363E19.2; Pkarb2; PKARIIbeta; PRKAR2; PRKAR2B; protein kinase cAMP-dependent type II regulatory subunit beta; protein kinase, cAMP dependent regulatory, type II beta; protein kinase, cAMP-dependent, regulatory subunit type II beta; protein kinase, cAMP-dependent, regulatory, type II, beta; RATDNA; RII(beta); RII-BETA; Type II beta regulatory subunit of cAMP-dependent protein kinase; WUGSC:H_RG363E19.2
• Gene Symbols: Prkar2b
• Host Species: Rabbit
• Immunogen: Synthetic peptide within Human PKA 2 beta aa 369-418.
• Purification Method: Protein A
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 19088, 24679, 5577
• Target Species: Human, Mouse, Rat
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG