PRKG2 Mouse anti-Human, Clone: OTI15E6, lyophilized, TrueMAB™

Mouse Monoclonal Antibody

Supplier:  OriGene CF807769

Catalog No. 50-166-8473

Description

Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO

cGKII is thought to play a key role in a diverse set of physiological pathway. cGKII may mediate intestinal secretion of water and electrolytes induced by the E. coli toxin STa and the intestinal peptide guanylin. Edentification of the pathway that mediates intestinal fluid secretion by E. coli STa has potential medical implications because STa causes traveler′s diarrhea and about 50% of infant mortality in developing countries. Transfection experiments in human cells disclose that cGKII phosphorylates SOX9 and attenuates SOX9 function by inhibiting its nuclear entry. Impaired differentiation of cultured KMI chondrocytes can be restored by silencing Sox9 by RNA interference. cGKII is postulated to be a molecular switch that couples the cessation of proliferation and the start of hypertrophic chondrocyte differentiation through attenuating SOX9 function.

Specifications

• Antigen: PRKG2
• Classification: Monoclonal
• Conjugate: Unconjugated
• Gene: PRKG2
• Gene Alias: PRKGR2, cGK2, cGKII
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 5593
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized

• Applications: Western Blot
• Clone: OTI15E6
• Formulation: PBS with 8% trehalose and no preservative; pH 7.3
• Gene Accession No.: Q13237
• Gene Symbols: PRKG2
• Immunogen: Human recombit protein fragment corresponding to amino acids 40-320 of human PRKG2 produced in E.coli.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1