Invitrogen™ PRL3 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA596031

Catalog No. PIPA596031

Description

Immunogen sequence: MARMNRPAPV EVSYKHMRFL ITHNPTNATL STFIEDLKKY GATTVVRVCE VTYDKTPLEK DGITVVDWPF DDGAPPPGKV VEDWLSLVKA KFCEAPGSCV AVHCVAGLGR KRRGAINSKQ LTYLEKYRPK QRLRFKDPHT HKTRCCVM; Positive Samples: K-562, 293T; Cellular Location: Cell membrane, Early endosome.

The protein encoded by this gene belongs to a small class of prenylated protein tyrosine phosphatases (PTPs). PTPs are cell signaling molecules that play regulatory roles in a variety of cellular processes. This class of PTPs contain a PTP domain and a characteristic C-terminal prenylation motif. Studies of this class of PTPs in mice demonstrated that they were prenylated proteins in vivo, which suggested their association with cell plasma membrane. Overexpression of this gene in mammalian cells was reported to inhibit angiotensin-II induced cell calcium mobilization and promote cell growth. Two alternatively spliced variants exist. PRL-3 expression was found to be up-regulated in human liver carcinoma compared with normal liver. Its expression in colorectal cancers may contribute to the establishment of liver metastasis. In a different study, PRL-3 is found to be expressed in tumor metastasis and vasculature, regardless of the tumor source.

Specifications

• Antigen: PRL3
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Ptp4a3
• Gene Alias: AV088979; HPRL-3; potentially prenylated protein tyrosine phosphatase; pPtp4a3; PRL3; Prl-3; PRL-R; protein tyrosine phosphatase 4a3; protein tyrosine phosphatase type IVA 3; protein tyrosine phosphatase type IVA, member 3; protein-tyrosine phosphatase 4a3; Protein-tyrosine phosphatase of regenerating liver 3; Ptp4a3
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 11156, 19245
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.61 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: O75365, Q9D658
• Gene Symbols: Ptp4a3
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-148 of human PTP4A3 (NP_0090102).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG